Evidence map›Paper›PMID 30723511›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2019

Natural Killer Response and Lipo-Metabolic Profile in Adults with Low HDL-Cholesterol and Mild Hypercholesterolemia: Beneficial Effects of Artichoke Leaf Extract Supplementation.

M Rondanelli, A M Castellazzi, A Riva, P Allegrini, M A Faliva, G Peroni, M Naso, M Nichetti, C Tagliacarne, C Valsecchi and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. A Phytochemical and Biological Characterization ofMolecules (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

M RondanelliIRCCS Mondino Foundation, Italy.ORCID 0000-0001-8336-4851
A M CastellazziDepartment of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
A RivaResearch and Development Unit, Indena, Milan, Italy.ORCID 0000-0003-2819-943X
P AllegriniResearch and Development Unit, Indena, Milan, Italy.
M A FalivaEndocrinology and Nutrition Unit, Section of Human Nutrition, ASP Pavia, University of Pavia, 27100, Pavia, Italy.
G PeroniEndocrinology and Nutrition Unit, Section of Human Nutrition, ASP Pavia, University of Pavia, 27100, Pavia, Italy.ORCID 0000-0002-1632-1787
M NasoEndocrinology and Nutrition Unit, Section of Human Nutrition, ASP Pavia, University of Pavia, 27100, Pavia, Italy.
M NichettiEndocrinology and Nutrition Unit, Section of Human Nutrition, ASP Pavia, University of Pavia, 27100, Pavia, Italy.
C TagliacarneDepartment of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
C ValsecchiDepartment of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
T FaziaDepartment of Brain and Behavioral Science, University of Pavia, Pavia, Italy.
S PernaDepartment of Biology, College of Science, University of Bahrain, Sakhir Campus, P.O. Box 32038, Bahrain.ORCID 0000-0002-2720-1473
F GrazianoDepartment of Brain and Behavioral Science, University of Pavia, Pavia, Italy.
M GrassiDepartment of Brain and Behavioral Science, University of Pavia, Pavia, Italy.
L BernardinelliDepartment of Brain and Behavioral Science, University of Pavia, Pavia, Italy.
University of Pavia · ITIndena (Italy) · ITUniversity of Bahrain · BH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study is to evaluate the effects of 60-day artichoke leaf extract (ALE) supplementation (250mg, twice daily) on cytokines levels, natural killer cell (NK) response, and lipo-metabolic profile (HDL, LDL, and total-cholesterol, triglycerides (TG), ApoB, ApoA, lipid accumulation product (LAP), glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR)) in twenty adults (9/11 males/females, age=49.10 ± 13.74 years, and BMI=33.12 ± 5.14 kg/m

Identifiers

PMID30723511
PMCPMC6339758
OpenAlexW2906697031

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.