Evidence map›Paper›PMID 30723467›Full record

ArticleFrontiers in immunology2019

Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.

Jan B Boscheinen, Sabrina Thomann, David M Knipe, Neal DeLuca, Beatrice Schuler-Thurner, Stefanie Gross, Jan Dörrie, Niels Schaft, Christian Bach, Anette Rohrhofer and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Jan B BoscheinenInstitute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Sabrina ThomannInstitute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
David M KnipeDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, United States.
Neal DeLucaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Beatrice Schuler-ThurnerDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Stefanie GrossDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Jan DörrieDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Niels SchaftDepartment of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Christian BachLab for Immunogenetics, Universitätsklinikum Erlangen, Erlangen, Germany.
Anette RohrhoferInstitute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany.
Melanie Werner-KleinChair of Immunology, Regensburg Center for Interventional Immunology (RCI), University of Regensburg, Regensburg, Germany.
Barbara SchmidtInstitute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Philipp SchusterInstitute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversitätsklinikum Erlangen · DEUniversity of Regensburg · DEHarvard University · USInstitute of Medical Microbiology and Hygiene · DEUniversity Hospital Regensburg · DEUniversity of Pittsburgh · US

Funding

International Herpes Vaccine ProjectR01AI057552 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KNIPE, DAVID M. · 2005 to 2014
$3.8M
International Herpes Vaccine ProjectR56AI057552 · NIAID · HARVARD MEDICAL SCHOOL · PI KNIPE, DAVID M. · 2011 to 2011
$70k
NIAID NIH HHS R01 AI057552NIAID NIH HHS R56 AI057552
6 · The paper itself

Abstract

Robust anti-tumor immunity requires innate as well as adaptive immune responses. We have shown that plasmacytoid dendritic cells develop killer cell-like activity in melanoma cell cocultures after exposure to the infectious but replication-deficient herpes simplex virus 1 (HSV-1)

Indexed as

Gene ExpressionHerpesvirus 1, HumanOncolytic VirusesTransgenesAntigen-Presenting CellsCD8-Positive T-LymphocytesCell Line, TumorFibroblastsGene TargetingGenetic EngineeringGenetic VectorsHumansLeukocytes, MononuclearMART-1 AntigenMelanomaT-LymphocytesMART-1 AntigenMLANA protein, humancytotoxic T cell responseherpes virusmalignant melanomaoncolytic virusesvaccine

Identifiers

PMID30723467
PMCPMC6349778
OpenAlexW2913044437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.