Evidence map›Paper›PMID 30723388›Full record

ArticleContrast media & molecular imaging2019

Visualizing the Distribution of Matrix Metalloproteinases in Ischemic Brain Using In Vivo

Vincent J Huber, Hironaka Igarashi, Satoshi Ueki, Mika Terumitsu-Tsujita, Chikako Nito, Ken Ohno, Yuji Suzuki, Kosuke Itoh, Ingrid L Kwee, Tsutomu Nakada

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contrast media & molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Vincent J HuberCenter for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.
Hironaka IgarashiCenter for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.ORCID 0000-0003-1663-5564
Satoshi UekiCenter for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.
Mika Terumitsu-TsujitaAdministrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Chikako NitoDepartment of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Ken OhnoCenter for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.
Yuji SuzukiCenter for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.ORCID 0000-0002-7525-0632
Kosuke ItohCenter for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.
Ingrid L KweeDepartment of Neurology, University of California Davis, Davis, CA, USA.
Tsutomu NakadaCenter for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.
Niigata University · JPNational Center of Neurology and Psychiatry · JPNippon Medical School · JPUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix metalloproteinases (MMPs) damage the neurovascular unit, promote the blood-brain barrier (BBB) disruption following ischemic stroke, and play essential roles in hemorrhagic transformation (HT), which is one of the most severe side effects of thrombolytic therapy. However, no biomarkers have presently been identified that can be used to track changes in the distribution of MMPs in the brain. Here, we developed a new

Indexed as

AnimalsBlood-Brain BarrierBrain IschemiaFluorine-19 Magnetic Resonance ImagingMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 3Matrix Metalloproteinase 9Matrix MetalloproteinasesMiceMice, Inbred C57BLMice, KnockoutMatrix Metalloproteinase 2Matrix Metalloproteinase 3Matrix Metalloproteinase 9Matrix Metalloproteinases

Identifiers

PMID30723388
PMCPMC6339703
OpenAlexW2907556942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.