ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
The susceptibility to chronic social defeat stress is related to low hippocampal extrasynaptic NMDA receptor function.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- A history of chronic adolescent stress attenuates cued fear-potentiated startle in adult female Wistar rats.Psychopharmacology · 2026Article
- Adenosine A2A signaling in mood disorders: How far have we come?IBRO neuroscience reports · 2025Article
- Comparing the Efficacy of Escitalopram with and without Crocin in Restoring I/O Functions and LTP within the Hippocampal CA1 Region of Stressed Rats.Advanced biomedical research · 2024Article
- Deficits in integrative NMDA receptors caused by Grin1 disruption can be rescued in adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Visualizing traumatic stress-induced structural plasticity in a medial amygdala pathway using mGRASP.Frontiers in molecular neuroscience · 2023Article
- Stress vulnerability shapes disruption of motor cortical neuroplasticity.Translational psychiatry · 2022Article
- Resilience to the effects of social stress on vulnerability to developing drug addiction.World journal of psychiatry · 2022Review
- Promises and Pitfalls of NMDA Receptor Antagonists in Treating Violent Aggression.Frontiers in behavioral neuroscience · 2022Article
- Alteration in NMDAR subunits in different brain regions of chronic unpredictable mild stress (CUMS) rat model.Translational neuroscience · 2022Article
- Opposing Changes in Synaptic and Extrasynaptic N-Methyl-D-Aspartate Receptor Function in Response to Acute and Chronic Restraint Stress.Frontiers in molecular neuroscience · 2021Article
- Reduced Consolation Behaviors in Physically Stressed Mandarin Voles: Involvement of Oxytocin, Dopamine D2, and Serotonin 1A Receptors Within the Anterior Cingulate Cortex.The international journal of neuropsychopharmacology · 2020Article
- Animal models of major depression: drawbacks and challenges.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
N-methyl-D-aspartate receptors (NMDARs) have been highly implicated in the pathogenesis and treatment of depression. While NMDARs can be found inside and outside glutamate synapses, it remains unclear if NMDARs at synaptic (sNMDAR) and extrasynaptic locations (exNMDAR) play different roles in the formation of depression-related behaviors. Using chronic social defeat stress (CSDS), an animal model for anxiety- and depression-related behaviors, we found that mice susceptible to CSDS exhibited low hippocampal exNMDAR function. Raising exNMDAR function by enhancing the release of glutamate from astrocytic cystine-glutamate antiporters or targeting extrasynaptic receptors with agonist-coated gold nanoparticles that cannot enter the synaptic cleft prevented social avoidance behavior in stressed mice. Interestingly, ketamine, which is a fast-acting antidepressant, exhibited stronger blockade to sNMDARs than to exNMDARs. These findings suggest that the susceptibility and resilience of mice toward CSDS is related to low and high exNMDAR function in the hippocampus, respectively. Enhancing exNMDAR function could be a novel treatment approach for mood and anxiety disorders.
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