ArticleMolecular psychiatry2020
Alterations in white matter microstructure in individuals at persistent risk for psychosis.
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Longitudinal Structural MRI Findings in Individuals at Genetic and Clinical High Risk for Psychosis: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Baseline symptom-related white matter tracts predict individualized treatment response to 12-week antipsychotic monotherapies in first-episode schizophrenia.Translational psychiatry · 2024Trial
- Longitudinal Development of Neurocognitive Functioning and Gray Matter Volume in Youths With Recurrent Psychosis Spectrum Symptoms.Schizophrenia bulletin · 2025Article
- Stable White Matter Structure in the First Three Years After Psychosis Onset.Biological psychiatry global open science · 2025Article
- The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Air Pollution Exposure, Prefrontal Connectivity, and Emotional Behavior in Early Adolescence.Research report (Health Effects Institute) · 2025Article
- A narrative literature review of white matter microstructure in individuals at clinical high risk for psychosis.Psychoradiology · 2025Review
- White matter, cognition and psychotic-like experiences in UK Biobank.Psychological medicine · 2023Article
- Deviations from normative brain white and gray matter structure are associated with psychopathology in youth.Developmental cognitive neuroscience · 2022Article
- Comparison of two cognitive screening measures in a longitudinal sample of youth at-risk for psychosis.Schizophrenia research · 2022Article
- Development of brain behavior integration systems related to criminal culpability from childhood to young adulthood: Does it stop at 18 years?Journal of pediatric neuropsychology · 2021Article
- Psychosis symptoms following aberrant immunity in the brain.Neural regeneration research · 2021Article
- Longitudinal Development of Brain Iron Is Linked to Cognition in Youth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
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Authors and funding
14 authors.
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Abstract
Abnormalities in brain white matter (WM) are reported in youth at-risk for psychosis. Yet, the neurodevelopmental time course of these abnormalities remains unclear. Thus, longitudinal diffusion-weighted imaging (DWI) was used to investigate WM abnormalities in youth at-risk for psychosis. A subset of individuals from the Philadelphia Neurodevelopmental Cohort (PNC) completed two DWI scans approximately 20 months apart. Youths were identified through structured interview as having subthreshold persistent psychosis risk symptoms (n = 46), and were compared to healthy typically developing participants (TD; n = 98). Analyses were conducted at voxelwise and regional levels. Nonlinear developmental patterns were examined using penalized splines within a generalized additive model. Compared to TD, youth with persistent psychosis risk symptoms had lower whole-brain WM fractional anisotropy (FA) and higher radial diffusivity (RD). Voxelwise analyses revealed clusters of significant WM abnormalities within the temporal and parietal lobes. Lower FA within the cingulum bundle of hippocampus and cerebrospinal tracts were the most robust deficits in individuals with persistent psychosis symptoms. These findings were consistent over two visits. Thus, it appears that WM abnormalities are present early in youth with persistent psychosis risk symptoms, however, there is little evidence to suggest that these features emerge in late adolescence or early adulthood. Future studies should seek to characterize WM abnormalities in younger individuals and follow individuals as subthreshold psychotic symptoms emerge.
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