Observational studyJournal of perinatology : official journal of the California Perinatal Association2019
Association of chorioamnionitis and its duration with neonatal morbidity and mortality.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 80 citations in OpenAlex.
- Intrauterine Contraction Monitoring in Chorioamnionitis: A Secondary, Blinded Analysis of a Randomised Controlled Trial Cohort.BJOG : an international journal of obstetrics and gynaecology · 2025Trial
- Factors associated with the development of neonatal acute respiratory distress syndrome in preterm infants: a retrospective cohort study.European journal of pediatrics · 2026Article
- Association of Chorioamnionitis with Early and Late Neonatal Sepsis in Preterm Infants with Gestational Age < 32 Weeks.Diagnostics (Basel, Switzerland) · 2026Article
- Isolation and characterization of Hofbauer cells from human term placentas.Frontiers in immunology · 2026Review
- Research progress on risk factors and clinical management ofFrontiers in pediatrics · 2026Review
- Funisitis increases the risk of death or cerebral palsy in extremely preterm infants.American journal of obstetrics and gynecology · 2025Article
- Survival Status and Predictors of Mortality Among Preterm Neonates Admitted to the Neonatal Intensive Care Units in Central Ethiopia: A Prospective Follow-Up Study.Public health challenges · 2025Article
- Zigzag Fetal Heart Rate Pattern in an Uncomplicated Pregnancy with Dual Intrauterine Infection Detected During Labor with Intact Membranes: A Case Report.Healthcare (Basel, Switzerland) · 2025Article
- The shifting landscape of the preterm brain.Neuron · 2025Review
- Inhaled nitric oxide therapy in preterm infants born before 34 weeks of gestation: a nationwide multicenter study.Italian journal of pediatrics · 2025Article
- Day-to-day dynamics of fetal heart rate variability to detect chorioamnionitis in preterm premature rupture of membranes.PloS one · 2025Article
- Effect of chorioamnionitis on necrotizing enterocolitis in preterm infants: a multicenter cohort study.Frontiers in pediatrics · 2025Article
- The role of placenta Hofbauer cells during pregnancy and pregnancy complications.Obstetrics & gynecology science · 2025Article
- Placental multimodal MRI prior to spontaneous preterm birth <32 weeks' gestation: An observational study.BJOG : an international journal of obstetrics and gynaecology · 2024Observational
- A Review of Emerging Viral Pathogens and Current Concerns for Vertical Transmission of Infection.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Mode of delivery in chorioamnionitis: impact on neonatal and maternal outcomes.BMC pregnancy and childbirth · 2024Article
- Associations between maternal bacteremia during the peripartum period and early-onset neonatal sepsis: a retrospective cohort study.BMC pediatrics · 2024Article
- Albumin and C-reactive protein as diagnostic markers for neonatal sepsis: a retrospective study.The Journal of international medical research · 2024Article
- Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.American journal of obstetrics and gynecology · 2024Review
- Adrenal volumes in fetuses delivering prior to 32 weeks' gestation: An MRI pilot study.Acta obstetricia et gynecologica Scandinavica · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the association of chorioamnionitis, and secondarily its duration, on neonatal adverse outcomes for infants born <34 weeks vs. ≥34 weeks. STUDY
designA secondary analysis from the observational U.S. Consortium on Safe Labor Study. The exposure was chorioamnionitis, and secondarily, its estimated duration. The composite outcome included pneumonia, seizure, necrotizing enterocolitis, sepsis, periventricular/intraventricular/cerebral hemorrhage, mechanical ventilation, and neonatal death. Multivariable logistic regression with generalized estimating equations was used, stratified by gestational age at delivery.
resultsAmong 221,274 deliveries, the odds of the neonatal adverse outcome <34 weeks was 2-fold higher among infants exposed to chorioamnionitis vs. those who were not (62.0 vs. 47.7%; AOR: 1.86; 95%CI: 1.25-2.75), and was ~3.5-fold higher ≥34 weeks (9.2 vs. 2.5%; AOR: 3.34; 95% CI: 2.35-4.76). The estimated duration of chorioamnionitis did not change the above associations.
conclusionsChorioamnionitis was associated with an approximately 2- and 3.5-fold increased odds of neonatal adverse outcomes <34 and ≥34 weeks, respectively, regardless of its estimated duration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.