Evidence map›Paper›PMID 30723185›Full record

ArticleSexually transmitted infections2019

Epidemiology of genital warts in the British population: implications for HPV vaccination programmes.

Pam Sonnenberg, Clare Tanton, David Mesher, Eleanor King, Simon Beddows, Nigel Field, Catherine H Mercer, Kate Soldan, Anne M Johnson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Partial Protective Effect of Bivalent Human Papillomavirus 16/18 Vaccination Against Anogenital Warts in a Large Cohort of Dutch Primary Care Patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  8. Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).International journal of environmental research and public health · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Pam SonnenbergMortimer Market Centre, Institute for Global Health, University College London, London, UK p.sonnenberg@ucl.ac.uk.
Clare TantonMortimer Market Centre, Institute for Global Health, University College London, London, UK.
David MesherCentre for Infectious Disease Surveillance and Control (CIDSC), Public Health England, London, UK.
Eleanor KingMortimer Market Centre, Institute for Global Health, University College London, London, UK.
Simon BeddowsVirus Reference Department, Public Health England, London, UK.
Nigel FieldMortimer Market Centre, Institute for Global Health, University College London, London, UK.
Catherine H MercerMortimer Market Centre, Institute for Global Health, University College London, London, UK.
Kate SoldanCentre for Infectious Disease Surveillance and Control (CIDSC), Public Health England, London, UK.
Anne M JohnsonMortimer Market Centre, Institute for Global Health, University College London, London, UK.
University College London · GBPublic Health England · GBMortimer Market Centre · GB

Funding

Medical Research Council G0701757Wellcome TrustWellcome Trust 084840
6 · The paper itself

Abstract

objectivesTo estimate the prevalence of, and describe risk factors for, genital warts (GWs) in the British population, following the introduction of the bivalent (human papillomavirus (HPV)-16/18) vaccination programme in girls, and prior to the switch to quadrivalent (HPV-6/11/16/18) vaccine (offering direct protection against GWs) and compare this with GW diagnoses in the prevaccination era.

methodsNatsal-3, a probability sample survey in Britain, conducted in 2010-2012, interviewed 9902 men and women aged 16-44. Natsal-2, conducted in 1999-2001, surveyed 11 161 men and women aged 16-44. Both surveys collected data on sexual behaviour and sexually transmitted infection diagnoses using computer-assisted interview methods.

resultsIn Natsal-3, 3.8% and 4.6% of sexually experienced men and women reported ever having a diagnosis of GWs, with 1.3% of men and 1.7% of woman reporting a GWs diagnosis in the past 5 years. GWs were strongly associated with increasing partner numbers and condomless sex. Diagnoses were more frequent in men who have sex with men (MSM) (11.6% ever, 3.3% past 5 years) and in women reporting sex with women (10.8% ever, 3.6% past 5 years). In the age group who were eligible for vaccination at the time of Natsal-3 (16-20 years), a similar proportion of same-aged women reported a history of GWs in Natsal-2 (1.9%, 1.1-3.4) and Natsal-3 (2.6%, 1.5-4.4).

conclusionsThese data provide essential parameters for mathematical models that inform cost-effectiveness analyses of HPV vaccination programmes. There was no evidence of population protection against GWs conferred by the bivalent vaccine. Even with vaccination of adolescent boys, vaccination should be offered to MSM attending sexual health clinics.

Indexed as

AdolescentAdultCondylomata AcuminataCost-Benefit AnalysisFemaleHumansMalePapillomaviridaePapillomavirus VaccinesPrevalenceSexual BehaviorUnited KingdomVaccinationYoung AdultPapillomavirus Vaccinesgenital wartsHPVprobability sample survey

Identifiers

PMID30723185
PMCPMC6678036
OpenAlexW2914202961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.