Evidence map›Paper›PMID 30723159›Full record

ArticleThe Journal of biological chemistry2019

Heparin affects cytosolic glucose responses of hyperglycemic dividing mesangial cells.

Andrew Jun Wang, Juan Ren, Amina Abbadi, Aimin Wang, Vincent C Hascall

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Targeting Macrophages: Therapeutic Approaches in Diabetic Kidney Disease.International journal of molecular sciences · 2024
    Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrew Jun WangFrom the Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195.
Juan RenFrom the Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195.
Amina AbbadiFrom the Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195.
Aimin WangFrom the Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195.
Vincent C HascallFrom the Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195 wanga@ccf.org.
Cleveland Clinic · US

Funding

VERSICAN PROTEOLYSIS AND REGULATION OF VASCULAR SMOOTH MUSCLEP01HL107147 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI DE LA MOTTE, CAROL A. · 2011 to 2017
$16.1M
Immersive Training in GlycosciencesK12HL141952 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASCALL, VINCENT CHARLES, SCHNAAR, RONALD L · 2018 to 2022
$4.8M
Monocyte Adhesive Hyaluronan Structures in DiabetesR01DK062934 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI WANG, AIMIN · 2004 to 2008
$1.2M
NHLBI NIH HHS K12 HL141952NHLBI NIH HHS P01 HL107147NIDDK NIH HHS R01 DK062934
6 · The paper itself

Abstract

Mesangial expansion underlies diabetic nephropathy, leading to sclerosis and renal failure. The glycosaminoglycan heparin inhibits mesangial cell growth, but the molecular mechanism is unclear. Here, rat mesangial cells (RMCs) were growth-arrested in the G

Indexed as

AnimalsCells, CulturedDose-Response Relationship, DrugExtracellular MatrixGlomerular MesangiumGlucoseGlucose Transporter Type 4HeparinHyperglycemiaInterphaseRatsGlucoseGlucose Transporter Type 4HeparinSlc2a4 protein, ratdiabetic nephropathyextracellular matrixglomerular lesionglucose transporter type 4 (GLUT4)glucose uptakehyaluronanhyperglycemiainflammationkidney diseasemesangial cells

Identifiers

PMID30723159
PMCPMC6484118
OpenAlexW2913887457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.