ArticleProceedings of the National Academy of Sciences of the United States of America2019
Genetically eliminating Purkinje neuron GABAergic neurotransmission increases their response gain to vestibular motion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Reference Frames for Encoding of Translation and Tilt in the Caudal Cerebellar Vermis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Purkinje cell dysfunction causes disrupted sleep in ataxic mice.Disease models & mechanisms · 2024Article
- Internal models of self-motion: neural computations by the vestibular cerebellum.Trends in neurosciences · 2023Review
- Interchangeable Role of Motor Cortex and Reafference for the Stable Execution of an Orofacial Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The otolith vermis: A systems neuroscience theory of the Nodulus and Uvula.Frontiers in systems neuroscience · 2022Article
- Article
- Translation information processing is regulated by protein kinase C-dependent mechanism in Purkinje cells in murine posterior vermis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Simple spike dynamics of Purkinje cells in the macaque vestibulo-cerebellum during passive whole-body self-motion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Purkinje neurons in the caudal cerebellar vermis combine semicircular canal and otolith signals to segregate linear and gravitational acceleration, evidence for how the cerebellum creates internal models of body motion. However, it is not known which cerebellar circuit connections are necessary to perform this computation. We first showed that this computation is evolutionarily conserved and represented across multiple lobules of the rodent vermis. Then we tested whether Purkinje neuron GABAergic output is required for accurately differentiating linear and gravitational movements through a conditional genetic silencing approach. By using extracellular recordings from lobules VI through X in awake mice, we show that silencing Purkinje neuron output significantly alters their baseline simple spike variability. Moreover, the cerebellum of genetically manipulated mice continues to distinguish linear from gravitational acceleration, suggesting that the underlying computations remain intact. However, response gain is significantly increased in the mutant mice over littermate controls. Altogether, these data argue that Purkinje neuron feedback regulates gain control within the cerebellar circuit.
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Registered trials
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