Evidence map›Paper›PMID 30723133›Full record

ArticlemBio2019

Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole.

Charles L Larson, Kelsi M Sandoz, Diane C Cockrell, Robert A Heinzen

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 32 citations in OpenAlex.

  1. TFEB and MCOLN1 are important forFrontiers in cellular and infection microbiology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Virulence · 2024
    Article
  8. Journal of bacteriology · 2024
    Article
  9. Article
  10. Archives of Razi Institute · 2023
    Review
  11. Eat or Be Eaten: Strategies Used byInfection and immunity · 2023
    Review
  12. MicroRNAs Contribute to Host Response toInfection and immunity · 2023
    Article
  13. Establishing the intracellular niche of obligate intracellular vacuolar pathogens.Frontiers in cellular and infection microbiology · 2023
    Review
  14. The intricate dance: host autophagy andFrontiers in microbiology · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Autophagy · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Charles L LarsonCoxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Kelsi M SandozCoxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Diane C CockrellCoxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Robert A HeinzenCoxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA rheinzen@niaid.nih.gov.ORCID 0000-0001-6870-4619
National Institutes of Health · US

Funding

Cellular and Developmental Biology of Coxiella burnetiiZIAAI000931 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HEINZEN, ROBERT A · 2009 to 2023
$11.8M
Intramural NIH HHS ZIA AI000931
6 · The paper itself

Abstract

The Q fever agent

Indexed as

Host-Pathogen InteractionsCoxiella burnetiiHumansMacrophagesMechanistic Target of Rapamycin Complex 1PhagosomesTHP-1 CellsMechanistic Target of Rapamycin Complex 1autophagyCoxiellacoxiella-containing vacuoleendolysosomal membraneslysosomemTorQ fevertype IV secretionvacuole

Identifiers

PMID30723133
PMCPMC6428759
OpenAlexW2913123388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.