Evidence map›Paper›PMID 30723125›Full record

ArticlemBio2019

Dopamine Is a Siderophore-Like Iron Chelator That Promotes

Stefanie Dichtl, Egon Demetz, David Haschka, Piotr Tymoszuk, Verena Petzer, Manfred Nairz, Markus Seifert, Alexander Hoffmann, Natascha Brigo, Reinhard Würzner and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Norepinephrine derepresses the Fur regulon ofJournal of bacteriology · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Dopamine promotesFrontiers in cellular and infection microbiology · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Availability of Ferritin-Bound Iron to Enterobacteriaceae.International journal of molecular sciences · 2022
    Article
  17. Article
  18. Survival and Virulence Potential of Drug-ResistantInternational journal of environmental research and public health · 2022
    Article
  19. Attenuation ofFrontiers in cellular and infection microbiology · 2022
    Article
  20. Nifedipine Potentiates Susceptibility ofAntibiotics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Stefanie DichtlDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-7657-329X
Egon DemetzDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
David HaschkaDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
Piotr TymoszukDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-0398-6034
Verena PetzerDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
Manfred NairzDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
Markus SeifertDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
Alexander HoffmannDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
Natascha BrigoDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
Reinhard WürznerDivision of Microbiology and Hygiene, Medical University of Innsbruck, Innsbruck, Austria.
Igor TheurlDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
Joyce E KarlinseyDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Ferric C FangDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA.ORCID 0000-0002-3243-110X
Günter WeissDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria guenter.weiss@i-med.ac.at.
Innsbruck Medical University · ATUniversity of Washington · US

Funding

Typhoid Pathogenesis and ImmunityR01AI112640 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2015 to 2019
$2.1M
Antimicrobial Actions of Nitric OxideR01AI118962 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2016 to 2020
$1.9M
Typhoid Pathogenesis and ImmunityR56AI112640 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2020 to 2020
$574k
Austrian Science Fund FWF I 3321Austrian Science Fund FWF W 1253NIAID NIH HHS R01 AI112640NIAID NIH HHS R01 AI118962NIAID NIH HHS R56 AI112640
6 · The paper itself

Abstract

We have recently shown that the catecholamine dopamine regulates cellular iron homeostasis in macrophages. As iron is an essential nutrient for microbes, and intracellular iron availability affects the growth of intracellular bacteria, we studied whether dopamine administration impacts the course of

Indexed as

AnimalsBacterial LoadCells, CulturedChelating AgentsDisease Models, AnimalDopamineIronLiverMacrophagesMice, Inbred C57BLSalmonella InfectionsSalmonella typhimuriumSiderophoresSpleenSurvival AnalysisVirulenceChelating AgentsDopamineIronSiderophorescatecholaminedopamineironqseCSalmonella Typhimuriumsepsis

Identifiers

PMID30723125
PMCPMC6428752
OpenAlexW2914031632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.