ReviewmBio2019
Host-Microbe Coevolution: Applying Evidence from Model Systems to Complex Marine Invertebrate Holobionts.
Review in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review: Long-Read Sequencing in Algal Studies.International journal of molecular sciences · 2026Pooled it
- Is a Commensal Here, a Pathogen There? Genotype Specific Responses by the Sea Anemone Nematostella vectensis to Vibrio Species.Molecular ecology · 2026Article
- Article
- Pseudoalteromonas is a symbiont of marine invertebrates that exhibits broad patterns of phylosymbiosis.The ISME journal · 2026Article
- Transcriptomic characterization of mucosal hemocytes in the eastern oyster (Frontiers in immunology · 2026Article
- Intracellular vesicle-mediated biomineralization of arsenic and barium by a sponge symbiotic bacterium.ISME communications · 2026Article
- Host Evolutionary History Drives Prokaryotic Diversity in the Globally Distributed Sponge Family Petrosiidae.Molecular ecology · 2025Article
- Review
- Article
- Article
- Microbiome of the Boring Giant Clam Provides Insights Into Holobiont Resilience Under Coral Reef Environmental Stress.Environmental microbiology · 2025Article
- Phylogenetic and functional diversity amongmSystems · 2025Article
- Multi-omics reveals the inhibition of asexual reproduction in the jellyfish Aurelia coerulea polyp by Bacillus pacificus.Environmental microbiome · 2025Article
- Plant Genetic Bases Associated With Microbiota Descriptors Shed Light Into a Novel Holobiont Generalist Genes Theory.Environmental microbiology · 2025Article
- Effects of Seawater from Different Sea Areas on Abalone Gastrointestinal Microorganisms and Metabolites.Microorganisms · 2025Article
- Symbiont-Mediated Metabolic Shift in the Sea Anemone Anthopleura elegantissima.Molecular ecology · 2025Article
- LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster.Cell communication and signaling : CCS · 2025Article
- Article
- A review of the venom microbiome and its utility in ecology and evolution including future directions for emerging research.Symbiosis (Philadelphia, Pa.) · 2025Article
- The role of animal hosts in shaping gut microbiome variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine invertebrates often host diverse microbial communities, making it difficult to identify important symbionts and to understand how these communities are structured. This complexity has also made it challenging to assign microbial functions and to unravel the myriad of interactions among the microbiota. Here we propose to address these issues by applying evidence from model systems of host-microbe coevolution to complex marine invertebrate microbiomes. Coevolution is the reciprocal adaptation of one lineage in response to another and can occur through the interaction of a host and its beneficial symbiont. A classic indicator of coevolution is codivergence of host and microbe, and evidence of this is found in both corals and sponges. Metabolic collaboration between host and microbe is often linked to codivergence and appears likely in complex holobionts, where microbial symbionts can interact with host cells through production and degradation of metabolic compounds. Neutral models are also useful to distinguish selected microbes against a background population consisting predominately of random associates. Enhanced understanding of the interactions between marine invertebrates and their microbial communities is urgently required as coral reefs face unprecedented local and global pressures and as active restoration approaches, including manipulation of the microbiome, are proposed to improve the health and tolerance of reef species. On the basis of a detailed review of the literature, we propose three research criteria for examining coevolution in marine invertebrates: (i) identifying stochastic and deterministic components of the microbiome, (ii) assessing codivergence of host and microbe, and (iii) confirming the intimate association based on shared metabolic function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.