Evidence map›Paper›PMID 30722716›Full record

ArticleThe Journal of international medical research2019

Role of irisin in Chinese patients with hypothyroidism: an interventional study.

Ning Yang, Heng Zhang, Xia Gao, Li Miao, Zhi Yao, Yuan Xu, Guang Wang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06699069 (The Effect of Exercise on Serum Irisin Levels in Hypothyroid Sprague Dawley Rats), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06699069 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of Exercise on Serum Irisin Levels in Hypothyroid Sprague Dawley Rats

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2022Enrolled30ConditionsHypothyroidismArmsControl or Euthyroid group, Hypothyroid group, Hypothyroid group received exercise
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. The role of thyroid hormone in metabolism and metabolic syndrome.Therapeutic advances in endocrinology and metabolism · 2020
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ning YangDepartment of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-6467-4560
Heng ZhangDepartment of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Xia GaoDepartment of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Li MiaoDepartment of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Zhi YaoDepartment of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Yuan XuDepartment of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Guang WangDepartment of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIrisin is a myokine that greatly affects energy expenditure and systemic metabolism. While thyroid hormone is likely associated with irisin, a direct relationship remains to be fully elucidated. This study aimed to investigate plasma irisin levels in Chinese patients with hypothyroidism.

methodsA total of 155 subjects were divided into the hypothyroidism group or the control group. Fifty-seven patients in the hypothyroidism group received levothyroxine treatment. Baseline irisin levels were measured in the two groups and post-treatment levels were measured in the hypothyroidism group.

resultsIrisin levels were significantly lower in the hypothyroidism group than in the control group. In the hypothyroidism group, irisin levels were positively associated with free triiodothyronine and free thyroxine levels, and negatively associated with thyrotropin levels. In the hypothyroidism group, irisin levels were significantly increased after levothyroxine treatment. Multiple linear regression models showed that total cholesterol and free thyroxine levels were the only significant predictors of serum irisin levels.

conclusionsIrisin levels are decreased in patients with hypothyroidism. Our results suggest that decreased irisin levels are directly associated with reduced thyroid hormone levels. These values may be restored after levothyroxine treatment in Chinese patients with hypothyroidism.

Indexed as

AdultBiomarkersCase-Control StudiesChinaEarly Medical InterventionFemaleFibronectinsFollow-Up StudiesHumansHypothyroidismMaleMiddle AgedPrognosisThyroid Function TestsThyroxineBiomarkersFibronectinsFNDC5 protein, humanThyroxinecreatine kinasehypothyroidismIrisinlevothyroxinemyokinethyroid hormone

Identifiers

PMID30722716
PMCPMC6460594
OpenAlexW2912480029

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.