ArticleJournal of experimental botany2019
Reduced expression of the proteolytically inactive FtsH members has impacts on the Darwinian fitness of Arabidopsis thaliana.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Genome-wide identification and characterization of filamentation temperature-sensitive H (FtsH) genes and expression analysis in response to multiple stresses in Medicago truncatula.Molecular biology reports · 2023Article
- Genome-Wide Identification and Comprehensive Analysis of theInternational journal of molecular sciences · 2023Article
- Chloroplast import motor subunits FtsHi1 and FtsHi2 are located on opposite sides of the inner envelope membrane.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Identification of circular RNAs of Cannabis sativa L. potentially involved in the biosynthesis of cannabinoids.Planta · 2023Article
- A systematicFrontiers in plant science · 2023Article
- Recent Advances in Understanding the Structural and Functional Evolution of FtsH Proteases.Frontiers in plant science · 2022Review
- Chlamydomonas proteases: classification, phylogeny, and molecular mechanisms.Journal of experimental botany · 2021Article
- Loss of Arabidopsis matrix metalloproteinase-5 affects root development and root bacterial communities during drought stress.Physiologia plantarum · 2021Article
- The FtsHi Enzymes ofInternational journal of molecular sciences · 2021Review
- Abundance of metalloprotease FtsH12 modulates chloroplast development in Arabidopsis thaliana.Journal of experimental botany · 2021Article
- Chloroplast Genome Evolution in Four Montane Zingiberaceae Taxa in China.Frontiers in plant science · 2021Article
- The Plastid-Localized AtFtsHi3 Pseudo-Protease ofFrontiers in plant science · 2021Article
- DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis.Journal of experimental botany · 2019Article
- Plant proteases and programmed cell death.Journal of experimental botany · 2019Article
- The Chloroplast Envelope Protease FTSH11 - Interaction With CPN60 and Identification of Potential Substrates.Frontiers in plant science · 2019Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
FtsH (filamentation-temperature-sensitive protein H) proteases are a family of membrane-bound enzymes present in eubacteria, animals, and plants. Besides the 12 genes encoding proteolytically active members of the FtsH family in the genome of Arabidopsis, there are five genes coding for members that are assumed to be proteolytically inactive due to mutations in the protease domain; these are termed FtsHi (i for inactive). Despite their lack of proteolytic activity, these FtsHi members seem to be important for chloroplast and plant development as four out of five homozygous knockout-mutants of FtsHis are embryo-lethal. Here, we analysed the Darwinian fitness of weak homozygous (ftshi1,3,4) and heterozygous (ftshi/FTSHi2,4,5) mutants. We compared the growth and development of these mutants to their respective wild-type Arabidopsis plants under controlled laboratory conditions and in the field, and we also evaluated the photosynthetic efficiency by pulse-amplitude modulation fluorescence. Homologous genotypes were subjected to various stress conditions in a greenhouse and gene co-expression as well as phylogenetic analyses were performed. Analysis of the gene-expression network of the five FTSHi genes indicated common clusters with genes encoding FtsH12, OTP51, and methylase. Phylogenetic analyses pointed to a common evolution (and common disappearance in grasses and gymnosperms) of FtsH12 and multiple presumably proteolytically inactive FtsHi enzymes. Our data show that the FtsHi enzymes are highly important during the seedling stage and for Darwinian fitness analyses in semi-natural conditions.
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