Evidence map›Paper›PMID 30721971›Full record

ReviewInternational immunology2019

Eavesdropping on the conversation between immune cells and the skin epithelium.

Shoiab Bukhari, Aaron F Mertz, Shruti Naik

Abstract readReview
In one paragraph

Review in International immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Epithelial-Dermal Immune Memory: TrackingInternational journal of molecular sciences · 2026
    Review
  2. Article
  3. Epithelial-immune crosstalk in health and disease.Current opinion in genetics & development · 2022
    Review
  4. One Size Does Not Fit All: Diversifying Immune Function in the Skin.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Review
  5. Article
  6. Loricrin: Past, Present, and Future.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shoiab BukhariDepartment of Pathology, Department of Medicine and Ronald O. Perelman Department of Dermatology, NYU School of Medicine, New York, NY, USA.
Aaron F MertzLaboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Shruti NaikDepartment of Pathology, Department of Medicine and Ronald O. Perelman Department of Dermatology, NYU School of Medicine, New York, NY, USA.

Funding

Harnessing the effects of Ror gamma t cells on epidermal stem cells and commensal microbes to promote efficient wound repairK22AI135099 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NAIK, SHRUTI · 2018 to 2019
$268k
NIAID NIH HHS K22 AI135099
6 · The paper itself

Abstract

The skin epithelium covers our body and serves as a vital interface with the external environment. Here, we review the context-specific interactions between immune cells and the epithelium that underlie barrier fitness and function. We highlight the mechanisms by which these two systems engage each other and how immune-epithelial interactions are tuned by microbial and inflammatory stimuli. Epithelial homeostasis relies on a delicate balance of immune surveillance and tolerance, breakdown of which results in disease. In addition to their canonical immune functions, resident and recruited immune cells also supply the epithelium with instructive signals to promote repair. Decoding the dialogue between immunity and the epithelium therefore has great potential for boosting barrier function or mitigating inflammatory epithelial diseases.

Indexed as

AnimalsEpithelial CellsHomeostasisHumansSkinDETCsepithelial immunityLangerhans cellsregeneration and repairregulatory T cells

Identifiers

PMID30721971
PMCPMC6626297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.