Evidence map›Paper›PMID 30721944›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2019

Multimodal Parcellations and Extensive Behavioral Profiling Tackling the Hippocampus Gradient.

Anna Plachti, Simon B Eickhoff, Felix Hoffstaedter, Kaustubh R Patil, Angela R Laird, Peter T Fox, Katrin Amunts, Sarah Genon

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna PlachtiInstitute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Simon B EickhoffInstitute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Felix HoffstaedterInstitute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Kaustubh R PatilInstitute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Angela R LairdDepartment of Physics, Florida International University, Miami, FL, USA.
Peter T FoxResearch Imaging Institute, University of Texas Health Science Center at San Antonio, TX, USA.
Katrin AmuntsInstitute of Neuroscience and Medicine (INM-1, INM-7), Research Centre Jülich, Jülich, Germany.
Sarah GenonInstitute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Meta-analysis in human brain mappingR56MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2020 to 2020
$543k
NIMH NIH HHS R01 MH074457NIMH NIH HHS R56 MH074457
6 · The paper itself

Abstract

The hippocampus displays a complex organization and function that is perturbed in many neuropathologies. Histological work revealed a complex arrangement of subfields along the medial-lateral and the ventral-dorsal dimension, which contrasts with the anterior-posterior functional differentiation. The variety of maps has raised the need for an integrative multimodal view. We applied connectivity-based parcellation to 1) intrinsic connectivity 2) task-based connectivity, and 3) structural covariance, as complementary windows into structural and functional differentiation of the hippocampus. Strikingly, while functional properties (i.e., intrinsic and task-based) revealed similar partitions dominated by an anterior-posterior organization, structural covariance exhibited a hybrid pattern reflecting both functional and cytoarchitectonic subdivision. Capitalizing on the consistency of functional parcellations, we defined robust functional maps at different levels of partitions, which are openly available for the scientific community. Our functional maps demonstrated a head-body and tail partition, subdivided along the anterior-posterior and medial-lateral axis. Behavioral profiling of these fine partitions based on activation data indicated an emotion-cognition gradient along the anterior-posterior axis and additionally suggested a self-world-centric gradient supporting the role of the hippocampus in the construction of abstract representations for spatial navigation and episodic memory.

Indexed as

AdultBrain MappingCluster AnalysisFemaleHippocampusHumansMagnetic Resonance ImagingMaleNeural PathwaysYoung Adultanterior–posteriorgradientmapmedial temporal lobestructural covariance

Identifiers

PMID30721944
PMCPMC6917521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.