ArticleAmerican journal of ophthalmology2019
Distinguishing Highly Asymmetric Keratoconus Eyes Using Dual Scheimpflug/Placido Analysis.
Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- A Novel Method for Analysing the Curvature of the Anterior Lens: Multi-Radial Scheimpflug Imaging and Custom Conic Fitting Algorithm.Journal of imaging · 2025Article
- Evaluating the Global Consensus on Keratoconus and Ectatic Diseases Agreements Reached on Subclinical Keratoconus.American journal of ophthalmology · 2025Review
- The Combined Utilization of Epithelial Thickness and Tomographic Parameters in Keratoconus Detection.Journal of ophthalmology · 2025Article
- Multimodal diagnostics for keratoconus and ectatic corneal diseases: a paradigm shift.Eye and vision (London, England) · 2023Review
- Keratoconus Diagnosis and Treatment: Recent Advances and Future Directions.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Enhanced Diagnostics for Corneal Ectatic Diseases: The Whats, the Whys, and the Hows.Diagnostics (Basel, Switzerland) · 2022Review
- Use of machine learning to achieve keratoconus detection skills of a corneal expert.International ophthalmology · 2022Article
- A Coincident Thinning Index for Keratoconus Identification Using OCT Pachymetry and Epithelial Thickness Maps.Journal of refractive surgery (Thorofare, N.J. : 1995) · 2020Article
- Biomechanical diagnostics of the cornea.Eye and vision (London, England) · 2020Review
- Galilei Corneal Tomography for Screening of Refractive Surgery Candidates: A Review of the Literature, Part II.Medical hypothesis, discovery & innovation ophthalmology journal · 2019Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeTo identify the best metrics or combination of metrics that provide the highest predictive power between normal eyes and the clinically unaffected eye of patients with highly asymmetric keratoconus using data from a Dual Scheimpflug/Placido device.
designRetrospective case-control study.
methodsCombined Dual Scheimpflug/Placido imaging was obtained from the Galilei G4 device (Ziemer Ophthalmic Systems AG, Port, Switzerland) in 31 clinically unaffected eyes with highly asymmetric keratoconus and 178 eyes from 178 patients with bilaterally normal corneal examinations that underwent uneventful LASIK with at least 1 year follow-up. Receiver operating characteristic (ROC) curves were generated to determine area under the curve (AUC), sensitivity, and specificity for 87 metrics, and logistic regression modeling was used to determine optimal variable combinations.
resultsNo individual metric achieved an AUC greater than 0.79. A combined model consisting of 9 metrics yielded an AUC of 0.96, with 90.3% sensitivity and 92.6% specificity. Among those 9 metrics included, 5 related to corneal pachymetry: Opposite Sector Index and Anterior Height BFS Z from the anterior surface, Asphericity and Asymmetry Index, Posterior Height BFS Z, and Posterior Height BFS X from the posterior surface. The strongest variable in the model was the thinnest point location on the horizontal (x) axis.
conclusionWhile individual metrics performed poorly, using a combination of metrics from the combined Dual Scheimpflug/Placido device provided a useful model for differentiating normal corneas from the clinically normal eyes of patients with highly asymmetric keratoconus. Pachymetry values were the most impactful metrics.
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Registered trials
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