ArticleInternational journal of colorectal disease2019
To what extent is the low anterior resection syndrome (LARS) associated with quality of life as measured using the EORTC C30 and CR38 quality of life questionnaires?
Article in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Effects of low anterior resection syndrome after colorectal cancer resections on health-related quality of life: a systematic review and meta-analysis.Techniques in coloproctology · 2025Pooled it
- Pooled it
- The impact of bowel dysfunction on health-related quality of life after rectal cancer surgery: a systematic review.Techniques in coloproctology · 2022Pooled it
- Developing a multivariable prediction model of global health-related quality of life in patients treated for rectal cancer: a prospective study in five countries.International journal of colorectal disease · 2024Trial
- Patient-reported outcomes in low anterior resection syndrome: a comparison of open and robotic surgery.International journal of colorectal disease · 2026Article
- Longitudinal assessment of quality of life and symptom burden in locally advanced rectal cancer patients receiving IMRT-based preoperative radiotherapy: A prospective cohort study.International journal of colorectal disease · 2025Article
- Evaluation of surgical strategy for low anterior resection syndrome using preoperative low anterior resection syndrome score in China.World journal of gastrointestinal surgery · 2025Article
- Diagnosis and Treatment of Low Anterior Resection Syndrome.Journal of the anus, rectum and colon · 2025Review
- Patient-reported outcomes after treatment for rectal cancer-A prospective nationwide study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2024Article
- Impact of Pilates Exercise on Quality of Life, Functional Capacity, Cancer-related Fatigue, Depression and Salivary Cortisol of Colorectal Cancer Survivors: A Quasi-Experimental Study.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Association between personality types and low anterior resection syndrome in rectal cancer patients following surgery.Cancer medicine · 2024Article
- Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment.Cancers · 2023Review
- Association between adherence to the American Cancer Society Nutrition and Physical Activity Guidelines and stool frequency among colon cancer survivors: a cohort study.Journal of cancer survivorship : research and practice · 2023Article
- Essential updates 2020/2021: Advancing precision medicine for comprehensive rectal cancer treatment.Annals of gastroenterological surgery · 2023Review
- Management of Low Anterior Resection Syndrome (LARS) Following Resection for Rectal Cancer.Cancers · 2023Review
- Article
- Patient-Reported Bowel and Urinary Function in Long-Term Survivors of Squamous Cell Carcinoma of the Anus Treated With Definitive Intensity Modulated Radiation Therapy And Concurrent Chemotherapy.International journal of radiation oncology, biology, physics · 2022Article
- Assessment of Quality of Life Following Radiotherapy in Patients with Rectum Cancer.Journal of gastrointestinal cancer · 2022Article
- Clinical Utility and Characteristics of the LARS Score Compared to the CCIS.World journal of surgery · 2022Observational
- Defecation disorder and anal function after surgery for lower rectal cancer in elderly patients.Annals of gastroenterological surgery · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTreatment of rectal cancer often results in disturbed anorectal function, which can be quantified by the Low Anterior Resection Syndrome (LARS) score. This study investigates the association of impaired anorectal function as measured with the LARS score with quality of life (QoL) as measured with the EORTC-QLQ-C30 and CR38 questionnaires.
methodsAll stoma-free patients who had undergone sphincter-preserving surgery for rectal cancer from 2000 to 2014 in our institution were retrieved from a prospective database. They were contacted by mail and asked to return the questionnaires. QoL was evaluated in relation to LARS and further patient- and treatment factors using univariate and multivariate analysis.
resultsOf the eligible patients (n = 331), 261 (78.8%) responded with a complete LARS score. Mean score for global QoL according to the EORTC-QLQ-C30 questionnaire was 63 ± 21 for all patients. If major LARS was present, mean score decreased to 56 ± 19 in contrast to 67 ± 20 in patients with no/minor LARS (p < 0.001). In regression analysis, major LARS was furthermore associated with reduced physical, role, emotional, cognitive and social functioning as well as impaired body image, more micturition problems and poorer future perspective. It was not related to sexual function. The variance explained by major LARS in the differences of QoL was approximately 10%.
conclusionThe presence of major LARS after rectal resection for cancer is negatively associated with global health as well as many other aspects of QoL. Preserving anorectal function and treatment of LARS are potential measures to improve QoL in this patient group.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.