ArticlePlant molecular biology2019
Opposite fates of the purine metabolite allantoin under water and nitrogen limitations in bread wheat.
Article in Plant molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Abiotic Stress in Crop Production.International journal of molecular sciences · 2023Pooled it
- Foliar application of allantoin and serotonin mitigates salinity stress in bitter melon (Momordica charantia L.).Scientific reports · 2026Article
- The response of Panax ginseng root microbial communities and metabolites to nitrogen addition.BMC plant biology · 2025Article
- Metabolite Profiling of the Resurrection GrassPlants (Basel, Switzerland) · 2025Article
- Nitrogen deficiency tolerance conferred by introgression of a QTL derived from wild emmer into bread wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Identification and Expression Analysis ofGenes · 2024Article
- Allantoin: A Potential Compound for the Mitigation of Adverse Effects of Abiotic Stresses in Plants.Plants (Basel, Switzerland) · 2023Review
- Combined Metabolomic and Transcriptomic Analysis Reveals Allantoin Enhances Drought Tolerance in Rice.International journal of molecular sciences · 2022Article
- Transcriptome and Metabolome Analyses Reveal Complex Molecular Mechanisms Involved in the Salt Tolerance of Rice Induced by Exogenous Allantoin.Antioxidants (Basel, Switzerland) · 2022Article
- Advances in Plant Metabolomics and Its Applications in Stress and Single-Cell Biology.International journal of molecular sciences · 2022Review
- Metabolite Profiling in Green Microalgae with Varying Degrees of Desiccation Tolerance.Microorganisms · 2022Article
- Uric acid extrarenal excretion: the gut microbiome as an evident yet understated factor in gout development.Rheumatology international · 2022Review
- CerealESTDb: A Comprehensive Resource for Abiotic Stress-Responsive Annotated ESTs With Predicted Genes, Gene Ontology, and Metabolic Pathways in Major Cereal Crops.Frontiers in genetics · 2022Article
- High-resolution association mapping with libraries of immortalized lines from ancestral landraces.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Targeted and untargeted metabolomics reveals deep analysis of drought stress responses in needles and roots ofFrontiers in plant science · 2022Article
- A New Perspective on the Role of Glutamine Synthetase in Nitrogen Remobilization in Wheat (International journal of molecular sciences · 2021Article
- Integration of Dual Stress Transcriptomes and Major QTLs from a Pair of Genotypes Contrasting for Drought and Chronic Nitrogen Starvation Identifies Key Stress Responsive Genes in Rice.Rice (New York, N.Y.) · 2021Article
- Mechanistic Insight of Allantoin in Protecting Tomato Plants Against Ultraviolet C Stress.Plants (Basel, Switzerland) · 2020Article
- Adaptation Strategies of Halophytic BarleyInternational journal of molecular sciences · 2020Article
- The intersection of nitrogen nutrition and water use in plants: new paths toward improved crop productivity.Journal of experimental botany · 2020Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 5 countries.
Funding
Abstract
key messageDegradation of nitrogen-rich purines is tightly and oppositely regulated under drought and low nitrogen supply in bread wheat. Allantoin is a key target metabolite for improving nitrogen homeostasis under stress. The metabolite allantoin is an intermediate of the catabolism of purines (components of nucleotides) and is known for its housekeeping role in nitrogen (N) recycling and also for its function in N transport and storage in nodulated legumes. Allantoin was also shown to differentially accumulate upon abiotic stress in a range of plant species but little is known about its role in cereals. To address this, purine catabolic pathway genes were identified in hexaploid bread wheat and their chromosomal location was experimentally validated. A comparative study of two Australian bread wheat genotypes revealed a highly significant increase of allantoin (up to 29-fold) under drought. In contrast, allantoin significantly decreased (up to 22-fold) in response to N deficiency. The observed changes were accompanied by transcriptional adjustment of key purine catabolic genes, suggesting that the recycling of purine-derived N is tightly regulated under stress. We propose opposite fates of allantoin in plants under stress: the accumulation of allantoin under drought circumvents its degradation to ammonium (NH
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