Evidence map›Paper›PMID 30720861›Full record

ReviewCA: a cancer journal for clinicians2019

Artificial intelligence in cancer imaging: Clinical challenges and applications.

Wenya Linda Bi, Ahmed Hosny, Matthew B Schabath, Maryellen L Giger, Nicolai J Birkbak, Alireza Mehrtash, Tavis Allison, Omar Arnaout, Christopher Abbosh, Ian F Dunn and 9 more

2 registry-linked trialsAbstract readReview
In one paragraph

Review in CA: a cancer journal for clinicians, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 953 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
953citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06001528 recruitingnot on this mapstarted 2021, after this paper: background citation

Serum and Tissue Metabolite-based Prediction of Sentinel Lymph Node Metastasis in Breast Cancer

TypeobservationalSponsorShantou Central HospitalRan2021 to 2026Enrolled2,400ConditionsBreast Cancer, Lymph Node Metastasis
NCT07500428 recruitingnot on this mapstarted 2026, after this paper: background citation

Construction of a Standardized Benchmark Evaluation System for Intelligent Breast Ultrasound Image Interpretation and Systematic Performance Assessment of Multimodal Artificial Intelligence Models Based on ACR BI-RADS v2025 Criteria

TypeobservationalSponsorPeking Union Medical College HospitalRan2026 to 2027Enrolled1,380ConditionsBreast Neoplasms, Breast Diseases, UltrasonographyArmsMultimodal AI Model Diagnostic Evaluation
3 · Its place in the literature

Who cites it

953 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Machine Learning-Driven radiomics on 18 F-FDG PET for glioma diagnosis: a systematic review and meta-analysis.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Pooled it
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Tumor metrics imaging core labs: primer for radiologists.Abdominal radiology (New York) · 2026
    Review
  12. Review
  13. AI agents in cancer imaging: Concepts, advances, and clinical perspectives.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

893 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Wenya Linda BiAssistant Professor of Neurosurgery, Department of Neurosurgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Ahmed HosnyResearch Scientist, Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Matthew B SchabathAssociate Member, Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Maryellen L GigerProfessor of Radiology, Department of Radiology, University of Chicago, Chicago, IL.
Nicolai J BirkbakResearch Associate, The Francis Crick Institute, London, United Kingdom.
Alireza MehrtashResearch Assistant, Department of Radiology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Tavis AllisonResearch Assistant, Department of Radiology, Columbia University College of Physicians and Surgeons, New York, NY.
Omar ArnaoutAssistant Professor of Neurosurgery, Department of Neurosurgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Christopher AbboshResearch Fellow, The Francis Crick Institute, London, United Kingdom.
Ian F DunnAssociate Professor of Neurosurgery, Department of Neurosurgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Raymond H MakAssociate Professor, Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Rulla M TamimiAssociate Professor, Department of Medicine, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Clare M TempanyProfessor of Radiology, Department of Radiology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Charles SwantonProfessor, The Francis Crick Institute, London, United Kingdom.
Udo HoffmannProfessor of Radiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Lawrence H SchwartzProfessor of Radiology, Department of Radiology, Columbia University College of Physicians and Surgeons, New York, NY.
Robert J GilliesProfessor of Radiology, Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Raymond Y HuangAssistant Professor, Department of Radiology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Hugo J W L AertsAssociate Professor, Departments of Radiation Oncology and Radiology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.ORCID 0000-0002-2122-2003

Funding

Image Guided Therapy Center - Ultrasound-based sensor system for the monitoring of COVID-19 patientsP41EB015898 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI TEMPANY, CLARE M · 2012 to 2021
$18.9M
Quantitative Imaging Clinical Validation Center at Moffitt Cancer CenterU01CA200464 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JOHN J HEINE, Matthew B. Schabath · 2016 to 2026
$9.2M
Radiomics of NSCLCU01CA143062 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GILLIES, ROBERT J., SCHABATH, MATTHEW B. · 2010 to 2020
$5.7M
Cellular, molecular and quantitative imaging analysis of screening-detected lung adenocarcinomaU01CA196405 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MALDONADO, FABIEN · 2015 to 2020
$5.4M
Quantitative Radiomics System Decoding the Tumor PhenotypeU24CA194354 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.5M
Lesion Composition and Quantitative Imaging Analysis on Breast Cancer DiagnosisR01CA166945 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GIGER, MARYELLEN L., SHEPHERD, JOHN ALAN · 2013 to 2017
$3.3M
Genotype and Imaging Phenotype Biomarkers in Lung CancerU01CA190234 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.3M
Integrative molecular and imaging approaches for risk of subtype specific breastU01CA189240 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI BEDROSIAN, ISABELLE, EL-ZEIN, RANDA A · 2015 to 2019
$2.9M
Quantitative Image Analysis for Assessing Response to Breast Cancer TherapyU01CA195564 · NCI · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN L. · 2015 to 2019
$2.5M
Non-invasive evaluation of indeterminate pulmonary nodulesU01CA186145 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MASSION, PIERRE P. · 2015 to 2019
$2.0M
Cancer Research UKDepartment of HealthMedical Research Council FC001169Medical Research Council FC001202NCI NIH HHS R01 CA166945NCI NIH HHS U01 CA143062NCI NIH HHS U01 CA186145NCI NIH HHS U01 CA189240NCI NIH HHS U01 CA190234NCI NIH HHS U01 CA195564NCI NIH HHS U01 CA196405NCI NIH HHS U01 CA200464NCI NIH HHS U24 CA194354NIBIB NIH HHS P41 EB015898Wellcome Trust FC001169Wellcome Trust FC001202
6 · The paper itself

Abstract

Judgement, as one of the core tenets of medicine, relies upon the integration of multilayered data with nuanced decision making. Cancer offers a unique context for medical decisions given not only its variegated forms with evolution of disease but also the need to take into account the individual condition of patients, their ability to receive treatment, and their responses to treatment. Challenges remain in the accurate detection, characterization, and monitoring of cancers despite improved technologies. Radiographic assessment of disease most commonly relies upon visual evaluations, the interpretations of which may be augmented by advanced computational analyses. In particular, artificial intelligence (AI) promises to make great strides in the qualitative interpretation of cancer imaging by expert clinicians, including volumetric delineation of tumors over time, extrapolation of the tumor genotype and biological course from its radiographic phenotype, prediction of clinical outcome, and assessment of the impact of disease and treatment on adjacent organs. AI may automate processes in the initial interpretation of images and shift the clinical workflow of radiographic detection, management decisions on whether or not to administer an intervention, and subsequent observation to a yet to be envisioned paradigm. Here, the authors review the current state of AI as applied to medical imaging of cancer and describe advances in 4 tumor types (lung, brain, breast, and prostate) to illustrate how common clinical problems are being addressed. Although most studies evaluating AI applications in oncology to date have not been vigorously validated for reproducibility and generalizability, the results do highlight increasingly concerted efforts in pushing AI technology to clinical use and to impact future directions in cancer care.

Indexed as

Artificial IntelligenceDiagnostic ImagingHumansNeoplasmsartificial intelligencecancer imagingclinical challengesdeep learningradiomics

Identifiers

PMID30720861
PMCPMC6403009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.