Evidence map›Paper›PMID 30720734›Full record

ArticleMolecules (Basel, Switzerland)2019

Investigation of Permeation of Theophylline through Skin Using Selected Piperazine-2,5-Diones.

Aneta Pokorna, Pavel Bobal, Michal Oravec, Lucie Rarova, Janette Bobalova, Josef Jampilek

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Rethinking asthma therapy, part 2: transdermal strategies for adjunct asthma and allergy treatments.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026
    Review
  2. Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases.Journal of enzyme inhibition and medicinal chemistry · 2024
    Article
  3. Review
  4. Article
  5. Evaluating the preventive effect of metoclopramide and aminophylline on pain after deep vitrectomy.International journal of physiology, pathophysiology and pharmacology · 2022
    Article
  6. Heterocycles in Medicinal Chemistry.Molecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Aneta PokornaDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1946/1, 612 42 Brno, Czech Republic. pokorna.anetaa@gmail.com.
Pavel BobalDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1946/1, 612 42 Brno, Czech Republic. pavelbobal@yahoo.com.ORCID 0000-0002-8429-3810
Michal OravecGlobal Change Research Institute CAS, Belidla 986/4a, 603 00 Brno, Czech Republic. oravec.m@czechglobe.cz.
Lucie RarovaDepartment of Chemical Biology and Genetics, Centre of the Region Hana for Biotechnological and Agricultural Research, Faculty of Science, Palacky University, Slechtitelu 27, 783 71 Olomouc, Czech Republic. lucie.rarova@upol.cz.
Janette BobalovaInstitute of Analytical Chemistry of the CAS, Veveri 97, 602 00 Brno, Czech Republic. bobalova@iach.cz.
Josef JampilekRegional Centre of Advanced Technologies and Materials, Palacky University, Slechtitelu 27, 783 71 Olomouc, Czech Republic. josef.jampilek@gmail.com.ORCID 0000-0003-2003-9052
University of Veterinary Sciences Brno · CZCzech Academy of Sciences, Global Change Research Institute · CZCzech Academy of Sciences, Institute of Analytical Chemistry · CZRegional Centre of Advanced Technologies and Materials · CZUniversity Hospital Olomouc · CZ

Funding

Institutional support of the Institute of Analytical Chemistry of the CAS. RVO:68081715Ministerstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0/0.0/16_019/0000868Ministerstvo Školství, Mládeže a Tělovýchovy National Program of Sustainability I (LO1305)Ministerstvo Školství, Mládeže a Tělovýchovy National Sustainability Program (NPU I; Grant No. LO1415)
6 · The paper itself

Abstract

Transdermal administration of drugs that penetrate, in this case directly into the blood circulation, has many advantages and is promising for many drugs thanks to its easy application and good patient compliance. (

Indexed as

Skin AbsorptionCell Line, TumorHumansMolecular StructurePermeabilityPiperazineTheophyllinePiperazineTheophyllinecytotoxicityFranz diffusion cellHPLC determinationpermeationpiperazine-2,5-dionesskintheophylline

Identifiers

PMID30720734
PMCPMC6385378
OpenAlexW2914860006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.