Evidence map›Paper›PMID 30720689›Full record

ArticleTransplantation2019

Tandem Orthotopic Living Donor Liver Transplantation Followed by Same Donor Haploidentical Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency.

Alexandra F Freeman, Nada Yazigi, Nirali N Shah, David E Kleiner, Mark Parta, Prescott Atkinson, Theo Heller, Steven M Holland, Stuart S Kaufman, Khalid M Khan and 1 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Cryptosporidium infection in dedicator of cytokinesis 8 (DOCK 8) deficiency.The journal of allergy and clinical immunology. In practice
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Nada YazigiPediatric Liver Transplantation, Department of Pediatrics, MedStar Georgetown University Hospital, Washington, DC.
Nirali N ShahPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
David E KleinerLaboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Mark PartaClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD.
Prescott AtkinsonDivision of Pediatric Allergy, Asthma and Immunology, University of Alabama at Birmingham, Birmingham, AL.
Theo HellerLiver Diseases Branch, National Institute of Digestive, Diabetes, and Kidney Disease Institute, National Institutes of Health, Bethesda, MD.
Steven M HollandLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Stuart S KaufmanPediatric Liver Transplantation, Department of Pediatrics, MedStar Georgetown University Hospital, Washington, DC.
Khalid M KhanPediatric Liver Transplantation, Department of Pediatrics, MedStar Georgetown University Hospital, Washington, DC.
Dennis D HicksteinExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
National Cancer Institute · USNational Institutes of Health · USFrederick National Laboratory for Cancer Research · US

Funding

Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6M
Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
Primary Immune Deficiency ClinicZIAAI001247 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FREEMAN, ALEXANDRA · 2019 to 2025
$8.7M
Investigation of non-cirrhotic portal hypertension.ZIADK075008 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HELLER, THEO · 2009 to 2025
$4.5M
Allotransplant for DOCK8 deficiencyZIABC011374 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HICKSTEIN, DENNIS · 2011 to 2020
$3.0M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z99 CA999999NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

backgroundAn 11-year-old girl with dedicator of cytokinesis 8 (DOCK8) deficiency was proposed for potentially curative hematopoietic stem cell transplantation (HSCT), the donor being her haploidentical mother. However, end-stage liver disease caused by chronic Cryptosporidium infection required liver transplantation before HSCT.

methodsConsequently, a staged approach of a sequential liver transplant followed by a HSCT was planned with her mother as the donor for both liver and HSCT.

resultsThe patient successfully underwent a left-lobe orthotopic liver transplant; however, she developed a biliary leak delaying the HSCT. Notably, the recipient demonstrated 3% donor lymphocyte chimerism in her peripheral blood immediately before HSCT. Haploidentical-related donor HSCT performed 2 months after liver transplantation was complicated by the development of acyclovir-resistant herpes simplex virus viremia, primary graft failure, and sinusoidal obstruction syndrome. The patient died from sinusoidal obstruction syndrome-associated multiorgan failure with Candida sepsis on day +40 following HSCT.

conclusionsWe discuss the many considerations inherent to planning for HSCT preceded by liver transplant in patients with primary immunodeficiencies, including the role of prolonged immunosuppression and the risk of infection before immune reconstitution. We also discuss the implications of potential recipient sensitization against donor stem cells precipitated by exposure of the recipient to the donor lymphocytes from the transplanted organ.

Indexed as

AdultCalcineurin InhibitorsChildCryptosporidiosisCryptosporidiumFemaleGuanine Nucleotide Exchange FactorsHematopoietic Stem Cell TransplantationHumansLiver TransplantationLiving DonorsMothersMyeloablative AgonistsSevere Combined ImmunodeficiencyTransplantation ConditioningTransplantation, HaploidenticalCalcineurin InhibitorsDOCK8 protein, humanGuanine Nucleotide Exchange FactorsMyeloablative Agonists

Identifiers

PMID30720689
PMCPMC6667308
OpenAlexW2912762497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.