ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2019
Health-Related Quality of Life Among Survivors of Pediatric Sepsis.
Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Cognitive Health and Quality of Life After Surviving Sepsis: A Narrative Review.Journal of intensive care medicine · 2026Review
- Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria.BMC nephrology · 2025Article
- Complex Decision-Making in Paediatric Intensive Care: A Discussion Paper and Suggested Model.Journal of bioethical inquiry · 2025Article
- [Self-reported quality of life of pediatric patients discharged from the Intensive Care Unit].Revista espanola de salud publica · 2025Observational
- New sepsis-associated morbidity and mortality in pediatric oncology patients.Frontiers in oncology · 2025Article
- "You're listening but you're not hearing": qualitative exploration of parents' lived experience of paediatric sepsis.Frontiers in pediatrics · 2025Article
- A scoping review on pediatric sepsis prediction technologies in healthcare.NPJ digital medicine · 2024Article
- Oxygenation Severity Categories and Long-Term Quality of Life among Children who Survive Septic Shock.Journal of pediatric intensive care · 2024Article
- Article
- Frequency of and Risk Factors for Increased Healthcare Utilization After Pediatric Sepsis Hospitalization.Critical care medicine · 2024Observational
- Digital solutions in paediatric sepsis: current state, challenges, and opportunities to improve care around the world.The Lancet. Digital health · 2024Review
- "I Didn't Realize How Hard It Was Going to Be Just Transitioning Back into Life": A Qualitative Exploration of Outcomes for Survivors of Pediatric Septic Shock.Journal of pediatric intensive care · 2024Article
- Predicting functional and quality-of-life outcomes following pediatric sepsis: performance of PRISM-III and PELOD-2.Pediatric research · 2023Article
- Observational
- Outcomes of Children Surviving Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023Review
- Pediatric Sepsis Requiring Intensive Care Admission: Potential Structured Follow-Up Protocols to Identify and Manage New or Exacerbated Medical Conditions.Risk management and healthcare policy · 2023Review
- Association of Illness Severity With Family Outcomes Following Pediatric Septic Shock.Critical care explorations · 2022Article
- Computerized Clinical Decision Support Systems for the Early Detection of Sepsis Among Pediatric, Neonatal, and Maternal Inpatients: Scoping Review.JMIR medical informatics · 2022Article
- Physical Quality of Life of Sepsis Survivor Severely Malnourished Children after Hospital Discharge: Findings from a Retrospective Chart Analysis.Life (Basel, Switzerland) · 2022Article
- Sepsis-Related Brain MRI Abnormalities Are Associated With Mortality and Poor Neurological Outcome in Pediatric Sepsis.Pediatric neurology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesMortality from pediatric sepsis has steadily declined over the past several decades; however, little is known about morbidity among survivors. We aimed to determine the prevalence of and risk factors for failure to recover to baseline health-related quality of life following community-acquired pediatric sepsis.
designRetrospective cohort study.
settingSeattle Children's Hospital. PATIENTS: Children aged 1 month to 21 years admitted to the inpatient wards or ICUs from 2012 to 2015 who met 2005 consensus sepsis criteria within 4 hours of hospitalization and were enrolled in the hospital's Outcomes Assessment Program with baseline, admission, and post-discharge health-related quality of life data available.
interventionsNone. MEASUREMENTS AND MAIN
resultsWe assessed health-related quality of life with the Pediatric Quality of Life Inventory for pre-admission baseline, admission, and post-discharge (median, 31 d) status. We determined associations between patient and illness characteristics with failure to recover within 4.5 points of baseline at follow-up (the minimum clinically significant difference between two scores). Of 790 patients, 23.8% failed to recover to baseline health-related quality of life at follow-up. Factors associated with failure to recover were septic shock, older age, private insurance, complex chronic disease, immune compromise, CNS infection or bacteremia, ICU admission, and longer length of stay. On multivariable analysis controlling for time to follow-up, failure to recover was independently associated with septic shock (relative risk, 1.79; 95% CI, 1.24-2.58), older age (relative risk, 1.02/yr; 95% CI, 1.01-1.05), immune compromise (relative risk, 1.83; 95% CI, 1.40-2.40), and length of stay (relative risk, 1.03/d; 95% CI, 1.01-1.04).
conclusionsNearly one-quarter of children surviving hospitalization for community-acquired sepsis experienced a clinically significant deterioration in health-related quality of life. We identify risk factors for poor outcomes following sepsis and highlight the need for ongoing evaluation and treatment by primary and specialty care providers for pediatric sepsis survivors after hospital discharge.
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