ArticlePain2019
Experimental evaluation of central pain processes in young women with primary dysmenorrhea.
Article in Pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Routine Dysmenorrhea Screening in Adolescents: Recommendations for Timely Diagnosis and Treatment of Endometriosis.Journal of pediatrics. Clinical practice · 2026Article
- Integrating the Central Sensitization Inventory (CSI) into Neuropelveological Practice: A Systematic Review of Endometriosis and Overlapping Pelvic Pain Syndromes.Journal of clinical medicine · 2026Review
- A pharmacological rat model of recurrent pelvic pain exhibiting hyperalgesia and depression-like behaviors.iScience · 2026Article
- Exploring predictors of analgesic response in adult women regularly using NSAIDs: insights from a machine learning approach.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Endogenous mediators in regulating primary dysmenorrhea.Frontiers in cell and developmental biology · 2026Review
- Article
- Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Early pubertal timing is a risk factor for adolescent dysmenorrhea.npj women's health · 2025Article
- A multidimensional appraisal of early menstrual pain experience.American journal of obstetrics and gynecology · 2024Article
- Role of stress and physical activity on primary dysmenorrhea: A cross-sectional study.Narra J · 2024Article
- Reflections on the group dynamic in a group cognitive behavioral therapy intervention for young adult women with moderate to severe dysmenorrhea: a qualitative analysis.Journal of psychosomatic obstetrics and gynaecology · 2023Article
- Adaptive neuroplasticity in the default mode network contributing to absence of central sensitization in primary dysmenorrhea.Frontiers in neuroscience · 2023Article
- COVID-Related Distress Is Associated with Increased Menstrual Pain and Symptoms in Adult Women.International journal of environmental research and public health · 2022Article
- Myofascial Pain Syndrome in Women with Primary Dysmenorrhea: A Case-Control Study.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Prevalence of chronic pelvic pain and primary dysmenorrhea in women of reproductive age in Ecuador.BMC women's health · 2022Article
- Ultrasonography Comparison of Pelvic Floor and Abdominal Wall Muscles in Women with and without Dyspareunia: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2022Article
- Menstrual Pain and Elasticity of Uterine Cervix.Journal of clinical medicine · 2021Article
- "Tomorrow, I'll Be Fine": Impacts and coping mechanisms in adolescents and young adults with primary dysmenorrhoea.Journal of advanced nursing · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Primary dysmenorrhea (PD; menstrual pain without an underlying medical condition) is associated with enhanced pain sensitivity and temporal summation (TS) in adult women, which may reflect the presence of central pain processes. Research in this area has been limited by focusing on only adult populations and incomplete assessments of central sensitization. The current study explored both excitatory and inhibitory measures of pain processing in girls and young adult women with and without PD. Thirty-two young women with PD and 34 healthy controls underwent laboratory pain testing during each of 3 menstrual cycle phases (menstrual, ovulatory, and midluteal), which included measures of pain tolerance and threshold, TS, and conditioned pain modulation. Results indicated enhanced pain sensitivity in young women with PD as measured by heat pain tolerance and Average Pain50 (P50), compared with healthy controls. These group differences were evident at all phases of the menstrual cycle. No group differences in cold pain tolerance, TS, or conditioned pain modulation were evident at any phase of the menstrual cycle. These data suggest some evidence of central sensitization in young women with PD, although no evidence of enhanced excitatory or deficient inhibitory mechanisms were observed. Future research should focus on identifying other potential phenotypes for PD to determine those at risk of developing other pain problems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.