Evidence map›Paper›PMID 30720429›Full record

ArticleeLife2019

Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription.

Sarah K Stumper, Harini Ravi, Larry J Friedman, Rachel Anne Mooney, Ivan R Corrêa, Anne Gershenson, Robert Landick, Jeff Gelles

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  6. eLife · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sarah K StumperDepartment of Biochemistry, Brandeis University, Waltham, United States.
Harini RaviDepartment of Biochemistry, Brandeis University, Waltham, United States.
Larry J FriedmanDepartment of Biochemistry, Brandeis University, Waltham, United States.ORCID 0000-0003-4946-8731
Rachel Anne MooneyDepartment of Biochemistry, University of Wisconsin, Madison, United States.
Ivan R CorrêaNew England Biolabs, Ipswich, United States.
Anne GershensonDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, United States.ORCID 0000-0003-3124-9610
Robert LandickDepartment of Biochemistry, University of Wisconsin, Madison, United States.ORCID 0000-0002-5042-0383
Jeff GellesDepartment of Biochemistry, Brandeis University, Waltham, United States.ORCID 0000-0001-7910-3421
Brandeis University · USUniversity of Wisconsin–Madison · USNew England Biolabs (United States) · USUniversity of Massachusetts Amherst · US

Funding

STRUCTURE/FUNCTION OF TRANSCRIPTION COMPLEX RNA HAIRPINSR01GM038660 · NIGMS · WASHINGTON UNIVERSITY · PI Robert Landick · 1992 to 2026
$12.2M
Single-molecule visualization of transcription regulation mechanismsR01GM081648 · NIGMS · BRANDEIS UNIVERSITY · PI JEFF GELLES · 2007 to 2026
$7.4M
Macromolecular Structure MechanismT32GM007596 · NIGMS · BRANDEIS UNIVERSITY · PI OPRIAN, DANIEL D · 1985 to 2019
$4.5M
National Science Foundation MCB-0446220NIGMS NIH HHS R01 GM038660NIGMS NIH HHS R01 GM081648NIGMS NIH HHS R01GM081648NIGMS NIH HHS R01GM38660NIGMS NIH HHS T32 GM007596
6 · The paper itself

Abstract

RNA polymerases (RNAPs) contain a conserved 'secondary channel' which binds regulatory factors that modulate transcription initiation. In

Indexed as

Gene Expression Regulation, BacterialTranscription, GeneticDNA, BacterialDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsKineticsModels, GeneticPromoter Regions, GeneticProtein BindingRNA, RibosomalTranscriptional Elongation FactorsdksA protein, E coliDNA, BacterialDNA-Directed RNA PolymerasesEscherichia coli ProteinsGreB protein, E coliRNA, RibosomalTranscriptional Elongation Factorsbiochemistrychemical biologyCoSMoSDksAE. coliGreBsingle-molecule fluorescenceTIRF

Identifiers

PMID30720429
PMCPMC7028371
OpenAlexW2912134762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.