Evidence map›Paper›PMID 30720420›Full record

ArticleMicrobial genomics2019

'Candidatus Ornithobacterium hominis': insights gained from draft genomes obtained from nasopharyngeal swabs.

Susannah J Salter, Paul Scott, Andrew J Page, Alan Tracey, Marcus C de Goffau, Claire Cormie, Bernardo Ochoa-Montaño, Clare L Ling, Jiraporn Tangmanakit, Paul Turner and 1 more

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Characterization ofMicrobial genomics · 2026
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  9. Microorganisms · 2021
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Susannah J Salter1​Pathogen Genomics, Wellcome Sanger Institute, Hinxton, UK.
Paul Scott1​Pathogen Genomics, Wellcome Sanger Institute, Hinxton, UK.
Andrew J Page1​Pathogen Genomics, Wellcome Sanger Institute, Hinxton, UK.
Alan Tracey1​Pathogen Genomics, Wellcome Sanger Institute, Hinxton, UK.
Marcus C de Goffau1​Pathogen Genomics, Wellcome Sanger Institute, Hinxton, UK.
Claire Cormie1​Pathogen Genomics, Wellcome Sanger Institute, Hinxton, UK.
Bernardo Ochoa-Montaño2​Department of Biochemistry, University of Cambridge, Cambridge, UK.
Clare L Ling3​Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Jiraporn Tangmanakit3​Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Paul Turner4​Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Julian Parkhill1​Pathogen Genomics, Wellcome Sanger Institute, Hinxton, UK.
Wellcome Sanger Institute · GBAngkor Hospital for Children · KHMahidol University · THShoklo Malaria Research Unit · THUniversity of Cambridge · GB

Funding

Wellcome Trust 083735/Z/07/ZWellcome Trust 098051
6 · The paper itself

Abstract

'Candidatus Ornithobacterium hominis' represents a new member of the Flavobacteriaceae detected in 16S rRNA gene surveys of people from South-East Asia, Africa and Australia. It frequently colonizes the infant nasopharynx at high proportional abundance, and we demonstrate its presence in 42 % of nasopharyngeal swabs from 12-month-old children in the Maela refugee camp in Thailand. The species, a Gram-negative bacillus, has not yet been cultured, but the cells can be identified in mixed samples by fluorescent hybridization. Here, we report seven genomes assembled from metagenomic data, two to improved draft standard. The genomes are approximately 1.9 Mb, sharing 62 % average amino acid identity with the only other member of the genus, the bird pathogen Ornithobacterium rhinotracheale. The draft genomes encode multiple antibiotic-resistance genes, competition factors, Flavobacterium johnsoniae-like gliding motility genes and a homologue of the Pasteurella multocida mitogenic toxin. Intra- and inter-host genome comparison suggests that colonization with this bacterium is both persistent and strain exclusive.

Indexed as

Host-Pathogen InteractionsAdultBacterial ProteinsBacterial ToxinsCohort StudiesDrug Resistance, BacterialFemaleFlavobacteriaceae InfectionsHumansInfantInfant, NewbornMetagenomeNasopharynxOrnithobacteriumRetrospective StudiesRNA, Ribosomal, 16SBacterial ProteinsBacterial ToxinsPasteurella multocida toxinRNA, Ribosomal, 16SOrnithobacteriumPasteurella mitogenic toxinrespiratory tract microbiome

Identifiers

PMID30720420
PMCPMC6421346
OpenAlexW2803341312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.