ArticleJournal of psychiatry & neuroscience : JPN2019
Adolescent depression and brain development: evidence from voxel-based morphometry
Article in Journal of psychiatry & neuroscience : JPN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses.Depression and anxiety · 2024Pooled it
- Gray matter abnormalities in patients with major depressive disorder and social anxiety disorder: a voxel-based meta-analysis.Brain imaging and behavior · 2023Pooled it
- Systematic review: Electroconvulsive therapy for treatment-resistant mood disorders in children and adolescents.European child & adolescent psychiatry · 2023Pooled it
- Pathological fear, anxiety and negative affect exhibit distinct neurostructural signatures: evidence from psychiatric neuroimaging meta-analysis.Translational psychiatry · 2022Pooled it
- Childhood maltreatment and inflammatory biomarkers associated with depressive severity in adolescents with major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Examination of poverty trajectories and brain volume as predictors of adolescent depression.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Radon-related increases in depressive symptoms are explained by amygdala morphology and external locus of control.Neurotoxicology · 2026Article
- Identification of Longitudinal Associations Between Depressive Symptoms and EEG Functional Connectivity in Adolescents Receiving Antidepressant Treatment.Research square · 2026Article
- Nicotine dependence associated with e-cigarette use, depressive symptoms, and psychological resilience among northern Thai adolescents: a cross-sectional study.BMC psychology · 2026Article
- Personalized functional topography-based multisite brain age prediction modeling reveals divergent neurodevelopment in major depression.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Preliminary analysis of ayahuasca-induced anatomical alterations in the somatosensory cortex of juvenile non-human primates (Callithrix jacchus) subjected to chronic stress.Translational psychiatry · 2026Article
- Gray matter structural alterations in first-episode drug-naïve adolescents with major depressive disorder: a comprehensive morphological analysis study.Psychological medicine · 2025Article
- Scientific psychiatry within technical reach.World journal of psychiatry · 2025Article
- Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females.Scientific reports · 2025Article
- Pre-pandemic mental health and brain characteristics predict adolescent stress and emotions during the COVID-19 pandemic.PloS one · 2025Article
- Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry.International journal of ophthalmology · 2025Article
- The mediation role of gray matter volume in the relationship between childhood maltreatment and psychological resilience in adolescents with first-episode major depressive disorder.Translational psychiatry · 2024Article
- The role of affective control, strategy repertoire and subjective emotion regulation success in developmental internalising psychopathology.Scientific reports · 2024Article
- Multimodal abnormalities of brain structures in adolescents and young adults with major depressive disorder: An activation likelihood estimation meta-analysis.World journal of psychiatry · 2024Article
- Machine Learning-Based Prediction of Suicidal Thinking in Adolescents by Derivation and Validation in 3 Independent Worldwide Cohorts: Algorithm Development and Validation Study.Journal of medical Internet research · 2024Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
Background: Investigating adolescents and young adults may provide a unique opportunity to understand developmental aspects of the neurobiology of depression. During adolescence, a considerable physiologic reorganization of both grey and white matter of the brain takes place, and it has been suggested that differences in grey-matter volumes during adolescence may reflect different maturational processes. Methods: We investigated grey-matter volumes in a comparatively large sample (n = 103) of adolescents and young adults (aged 12 to 27 years), 60 of them with a diagnosis of current depression. Results: Replicating previous studies, we found a clear wholebrain effect of age: the older the participants, the lower their global grey-matter volumes, particularly in the paracingulate and prefrontal cortices. Contrasting depressed and healthy youth in a whole-brain approach, we found greater grey-matter volumes in the dorsolateral prefrontal cortex of those with depression. Furthermore, a region-of-interest analysis indicated lower grey-matter volumes in the hippocampus in participants with depression compared with healthy controls. Limitations: The present study was limited because of a skewed sex distribution, its cross-sectional design and the fact that some participants were taking an antidepressant. Conclusion: During adolescence, restructuring of the brain is characterized by marked decreases in prefrontal grey-matter volumes, interpreted as a correlate of brain maturation. Findings of greater volumes in the prefrontal cortex, particularly in younger adolescents with depression, may suggest that these participants were more prone to delayed brain maturation or increased neuroplasticity. This finding may represent a risk factor for depression or constitute an effect of developing depression.
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