Evidence map›Paper›PMID 30720083›Full record

ArticleMolecular medicine reports2019

Upregulation of ADAMTS‑7 and downregulation of COMP are associated with spontaneous abortion.

Yang Mu, Dan-Ni Zhou, Na-Na Yan, Jin-Li Ding, Jing Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yang MuReproductive Medicine Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Dan-Ni ZhouReproductive Medicine Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Na-Na YanReproductive Medicine Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Jin-Li DingReproductive Medicine Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Jing YangReproductive Medicine Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan University, Wuhan, Hubei 430060, P.R. China.
Renmin Hospital of Wuhan University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS‑7) has been revealed to serve an important role in inflammation‑associated diseases. However, the role of ADAMTS‑7 in spontaneous abortion (SA) remains unclear. In the present study, human and mouse decidual tissues were used to detect the expression of ADAMTS‑7 and cartilage oligomeric matrix protein (COMP) in mice with lipopolysaccharide (LPS)‑induced abortion (10 mice/group), and in SA humans and the corresponding control group (21 participants in the SA group and 15 participants in the control group). The results revealed that ADAMTS‑7 expression was upregulated and that COMP expression was downregulated in the mouse decidual tissue of the LPS‑induced abortion group, when compared with that of the normal control group. The results were further confirmed by western blot analysis and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis, which revealed increased ADAMTS‑7 and decreased COMP expression at the protein and mRNA levels in mice treated with LPS. Additionally, the expression of ADAMTS‑7 was negatively correlated with the expression of COMP in mice, with a correlation coefficient of ‑0.936 (P<0.001). In addition, the expression of ADAMTS‑7 and COMP exhibited was similar in the decidual tissue of SA patients when compared with the levels observed in the tissues of the normal control participants, as demonstrated by increased ADAMTS‑7 expression and decreased COMP expression. Western blotting and RT‑qPCR analysis revealed that ADAMTS‑7 was increased and COMP was decreased in the decidual tissue of SA subjects. The correlation analysis of ADAMTS‑7 and COMP in human decidual tissue also revealed a similar result, with a correlation coefficient of ‑0.836 (P<0.001). The results of the present study demonstrated that ADAMTS‑7 was upregulated and COMP was downregulated in the decidual tissues of humans and mice with SA, and a negative correlation was identified between the expression levels of ADAMTS‑7 and COMP, thereby providing novel evidence for a better understanding of the pathogenesis of SA, which may lead to improvements in the clinical pregnancy outcomes of these individuals.

Indexed as

Gene Expression RegulationAbortion, SpontaneousADAMTS7 ProteinAdultAnimalsBiomarkersCartilage Oligomeric Matrix ProteinDeciduaFemaleHumansImmunohistochemistryLipopolysaccharidesMicePregnancyADAMTS7 ProteinADAMTS7 protein, humanBiomarkersCartilage Oligomeric Matrix ProteinLipopolysaccharidesTSP5 protein, human

Identifiers

PMID30720083
PMCPMC6423623
OpenAlexW2914204292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.