Evidence map›Paper›PMID 30720072›Full record

ArticleMolecular medicine reports2019

MicroRNA‑124 improves functional recovery and suppresses Bax‑dependent apoptosis in rats following spinal cord injury.

Zhongyang Xu, Kefeng Zhang, Qian Wang, Yanping Zheng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  4. Transcriptomics Insights into Spinal Cord Injury for Therapy Development.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zhongyang XuDepartment of Orthopedics, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China.
Kefeng ZhangDepartment of Orthopedics, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China.
Qian WangDepartment of Orthopedics, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China.
Yanping ZhengDepartment of Orthopedics, Qilu Hospital Affiliated to Shandong University, Jinan, Shandong 250012, P.R. China.
Jining First People's Hospital · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) induces aberrant expression of microRNAs (miRNAs), causing various secondary injury responses, including inflammation, apoptosis and oxidative stress. However, the mechanisms underlying miRNA‑mediated apoptosis have not been fully elucidated. In the present study, a rat SCI model was established and a miRNA microarray was analyzed to detect miRNA expression profiles at different times post‑SCI. The Basso, Beattie and Bresnahan score, cresyl violet staining and terminal deoxynucleotidyl‑-transferase‑mediated dUTP nick end labeling staining were used to evaluate locomotor activity, lesion volume and neuronal cell apoptosis, respectively, at different time points post‑SCI. It was observed that numerous miRNAs were altered at 14 days post‑SCI and miR‑124 was one of the most notably downregulated miRNAs. The present results demonstrated that overexpression of miR‑124 by agomir‑124 improves functional recovery, decreases lesion size and suppresses neuronal cell apoptosis in a rat SCI model. Luciferase reporter assay demonstrated that miR‑124 inhibited apoptosis regulator BAX (Bax) expression, a key molecule in the activation of the mitochondrial apoptotic pathway, by targeting its 3'‑untranslated region in BV‑2 cells. Furthermore, restoration of Bax by pc‑DNA‑Bax inhibits the protective effect of miR‑124 in H2O2‑treated BV‑2 cells. Notably, the present results demonstrated that miR‑124 may block the mitochondrial apoptotic pathway by inhibiting Bax, cleaved‑caspase‑9 and cleaved‑caspase‑3 expression in rats following SCI. Collectively, the present results suggested that miR‑124 may improve functional recovery and supress neuronal cell apoptosis by blocking the mitochondrial apoptotic pathway in SCI rats, suggesting that miR‑124 may serve as a potential therapeutic target in SCI treatment.

Indexed as

3' Untranslated RegionsAnimalsApoptosisbcl-2-Associated X ProteinBiomarkersDisease Models, AnimalGene ExpressionGene Expression ProfilingMaleMicroRNAsMitochondriaNeuronsOxidative StressRatsRecovery of FunctionRNA Interference3' Untranslated Regionsbcl-2-Associated X ProteinBiomarkersMicroRNAsMIRN124 microRNA, rat

Identifiers

PMID30720072
PMCPMC6423616
OpenAlexW2913279959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.