ArticleEndoscopic ultrasound
Discontinuation of proton pump inhibitor use reduces the number of endoscopic procedures required for resolution of walled-off pancreatic necrosis.
Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05817721 (PROTon Pump Inhibitors and Stent OCclusion Rate Of Lumen Apposing Metal Stents), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PROTon Pump Inhibitors and Stent OCclusion Rate Of Lumen Apposing Metal Stents (PROTOCOL)
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- AEG-AESPANC-OPGE-SIED-SPG Ibero-Latin American Guidelines on Acute Pancreatitis (iLATAM-AP).United European gastroenterology journal · 2026Guideline
- Trial
- Guidelines for endoscopic treatment of postinflammatory pancreatic and peripancreatic fluid collections. Recommendations of the Endoscopic Surgery Section of the Association of Polish Surgeons, the Endoscopy Section of the Polish Society of Gastroenterology, the Polish Pancreatic Club, the Laparoscopic and Robotic Surgery Section of the Association of Polish Surgeons, and the Pancreatic Surgery Section of the Association of Polish Surgeons; formulated by an expert panel led by Prof. Mateusz Jagielski, MD, PhD.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025Review
- Article
- The Multidisciplinary Approach to Acute Necrotizing Pancreatitis.Journal of clinical medicine · 2025Review
- Infected pancreatic necrosis-Current trends in management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Early Endoscopic Interventions for Pancreatic Necrosis: Indications, Technique, and Outcomes.Digestive diseases and sciences · 2024Review
- Endoscopic Ultrasound-Guided Drainage of Pancreatic Fluid Collections: Not All Queries Are Already Solved.Medicina (Kaunas, Lithuania) · 2024Review
- Indications, Techniques and Future Perspectives of Walled-off Necrosis Management.Diagnostics (Basel, Switzerland) · 2024Review
- Time to think prime times for treatment of necrotizing pancreatitis: Pendulum conundrum.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2023Review
- Endoscopic therapies for walled-off necrosis.iGIE : innovation, investigation and insights · 2023Article
- Endoscopic transluminal drainage and necrosectomy for infected necrotizing pancreatitis: Progress and challenges.World journal of clinical cases · 2023Review
- Endoscopic ultrasound drainage of pancreatic fluid collections: do we know enough about the best approach?Therapeutic advances in gastroenterology · 2023Review
- Endoscopic step up: When and how.Surgery open science · 2022Article
- Lumen Apposition: A Changing Landscape in Therapeutic Endoscopy.Digestive diseases and sciences · 2022Review
- Management of pancreatic fluid collections.Translational gastroenterology and hepatology · 2022Review
- [Interventional endoscopic treatment in acute pancreatitis].Der Internist · 2021Review
- Endoscopic Transmural Drainage and Necrosectomy in Acute Necrotizing Pancreatitis: A Review.Journal of translational internal medicine · 2021Article
- Proton Pump Inhibitors Were Associated With Reduced Pseudocysts in Acute Pancreatitis: A Multicenter Cohort Study.Frontiers in pharmacology · 2021Article
- When Should We Perform Endoscopic Drainage and Necrosectomy for Walled-Off Necrosis?Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesEndoscopic drainage/debridement of symptomatic walled off necrosis (WON) using lumen-apposing metal stents (LAMS) is both safe and effective. While endoscopic management of WON is the standard approach to treatment, the ideal concomitant medical therapy remains unclear. The purpose of this study was to further elucidate the effect of proton pump inhibitor (PPIs) therapy on the technical and clinical success of endoscopic treatment of WON.
methodsTwo hundred and seventy-two patients in 8 centers with WON managed by endoscopic drainage using LAMS were evaluated. Patients were followed for at least 6 months following treatment. The patients were divided into two groups: Those that used PPIs continuously during the therapy and those not on PPIs continuously during the interval of therapy. Outcomes included but were not limited to technical success, clinical success, number of procedures performed, and adverse events.
resultsFrom 2013 to 2016, 272 patients underwent WON drainage with successful transmural LAMS placement. The two groups were split evenly into PPI users and non-PPI users, and matched in regards to demographics, etiology of pancreatitis, WON size, and location. There was no difference in the technical success between the two groups (100% vs. 98.8%, P = 1), or in clinical success rates (78.7% vs. 77.9%). There was a significant difference in the required number of direct endoscopic necrosectomies to achieve clinical success in the PPI vs. non-PPI group (3.2 vs. 4.6 respectively, P < 0.01). There were significantly more cases of stent occlusion in the non-PPI group vs. PPI group (9.5% vs. 20.1% P = 0.012), but all other documented adverse events were not significantly different.
conclusionDiscontinuing PPIs during endoscopic drainage and necrosectomy of symptomatic WON appears to reduce the number of endoscopic procedures required to achieve resolution. Continuous PPI results in higher rates of early stent occlusion.
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