Evidence map›Paper›PMID 30719681›Full record

ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2019

Implications of sequence variation on the evolution of rRNA.

Matthew M Parks, Chad M Kurylo, Jake E Batchelder, C Theresa Vincent, Scott C Blanchard

Erratum issuedOpen access · hybridAbstract readReview
In one paragraph

Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Dynamic evolution and hierarchical regulation of rDNA in polyploid oat.The Plant journal : for cell and molecular biology · 2026
    Article
  2. Evidence for strong purifying selection of humanProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  5. Article
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  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Matthew M ParksDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Chad M KuryloDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Jake E BatchelderDepartment of Immunology, Weill Cornell Medicine, New York, NY, USA.
C Theresa VincentDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. theresa.vincent@igp.uu.se.
Scott C BlanchardDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. scb2005@med.cornell.edu.ORCID http://orcid.org/0000-0003-2717-9365
Cornell University · USUppsala University · SE

Funding

Imaging Protein Synthesis on the Ribosome using Single-Molecule FRETR01GM079238 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANCHARD, SCOTT C · 2006 to 2023
$7.0M
NIGMS NIH HHS R01 GM079238
6 · The paper itself

Abstract

The evolution of the multi-copy family of ribosomal RNA (rRNA) genes is unique in regard to its genetics and genome evolution. Paradoxically, rRNA genes are highly homogenized within and between individuals, yet they are globally distinct between species. Here, we discuss the implications for models of rRNA gene evolution in light of our recent discoveries that ribosomes bearing rRNA sequence variants can affect gene expression and physiology and that intra-individual rRNA alleles exhibit both context- and tissue-specific expression.

Indexed as

Evolution, MolecularGenetic VariationAllelesAnimalsDNA, RibosomalGene Expression RegulationHumansOrgan SpecificityProtein BiosynthesisRNA, RibosomalDNA, RibosomalRNA, Ribosomalconcerted evolutiongenome evolutionprotein synthesisrDNAribosomal RNArRNAspecialized ribosomes

Identifiers

PMID30719681
PMCPMC6505490
OpenAlexW2913479114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.