ReviewWorld journal of urology2019
Optimizing male fertility: oxidative stress and the use of antioxidants.
Review in World journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Health promoting spirulina platensis nanoparticles induce early embryonic loss in heat-stressed rabbit does.Scientific reports · 2026Article
- Reductive stress and the role of antioxidants in male infertility: a narrative review.Archives of gynecology and obstetrics · 2025Review
- Exploring the Effects of Oxidative Stress on Female Reproductive Function: The Role of Antioxidant Supplementation.Current drug metabolism · 2025Review
- Secretome of human amniotic membrane stem cells promote recovery and testicular functions through modulatingInternational journal of reproductive biomedicine · 2024Article
- Correlation of Dietary Macro- and Micro-Mineral Intake with Seminal Plasma Quality/Quantity and Oxidant/Antioxidant Status in Infertile Compared to the Normal Men: a Case-Control Study.Biological trace element research · 2024Article
- Effect ofPharmaceuticals (Basel, Switzerland) · 2024Article
- The Influence of Metabolic Factors and Diet on Fertility.Nutrients · 2023Review
- Impact of Cigarette Smoking on the Expression of Oxidative Stress-Related Genes in Cumulus Cells Retrieved from Healthy Women Undergoing IVF.International journal of molecular sciences · 2021Article
- Highly Cited Articles in the Field of Male Infertility and Antioxidants: A Scientometric Analysis.The world journal of men's health · 2021Article
- Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence.The world journal of men's health · 2021Review
- Effectiveness of Pharmacological Intervention Among Men with Infertility: A Systematic Review and Network Meta-Analysis.Frontiers in pharmacology · 2021Article
- Changes in Expressions of Spermatogenic Marker Genes and Spermatogenic Cell Population Caused by Stress.Frontiers in endocrinology · 2021Article
- The Effect of N-Acetyl-Cysteine onInternational journal of fertility & sterility · 2020Article
- Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos.Antioxidants (Basel, Switzerland) · 2020Review
- Diet and Nutritional Factors in Male (In)fertility-Underestimated Factors.Journal of clinical medicine · 2020Review
- The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia.Clinical and experimental reproductive medicine · 2019Article
- Topic issue: men's health in 2019.World journal of urology · 2019Article
- Article
- Water- and Fat-Soluble Antioxidants in Human Seminal Plasma and Serum of Fertile Males.Antioxidants (Basel, Switzerland) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeManagement of male infertility is always a difficult task, with pathophysiology and available treatments often poorly understood. The purpose of this review was to summarize current evidence regarding the use of protective agents against reactive oxygen species (ROS), such as antioxidants that may be useful in the treatment of male factor infertility.
methodsFor this publication, a search of studies concerning oxidative stress, male infertility and antioxidant therapy was performed using the search engines ScienceDirect, OVID, PubMed and MEDLINE. Articles published in languages other than English were not considered.
resultsAn interest in the physiologic and pathologic effects of ROS has grown. Nevertheless, use of antioxidants is challenging, considering the balance between physiological ROS activity and detrimental oxidative stress level. Several studies have shown positive outcomes in terms of semen parameters, with others having failed to do so. Available evidence is still limited in pregnancy and live birth rates.
conclusionsProtective agents against ROS, such as antioxidants, may have positive effects on semen parameters in some patients, although a widespread indication is still restricted by practical aspects, including unknown physiological levels of ROS and controversy regarding different concentrations and combinations of drugs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.