Evidence map›Paper›PMID 30719559›Full record

ArticleWorld journal of surgery2019

Primary Squamous Cell Carcinoma in the Thyroid Gland: A Population-Based Analysis Using the SEER Database.

Shuwen Yang, Cunfu Li, Xiao Shi, Ben Ma, Weibo Xu, Hongyi Jiang, Wanlin Liu, Qinghai Ji, Yu Wang

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Article in World journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shuwen YangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Cunfu LiDepartment of Thyroid Surgery, Weihai Central Hospital, Weihai, 264400, China.
Xiao ShiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Ben MaDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Weibo XuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Hongyi JiangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Wanlin LiuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Qinghai JiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Yu WangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. neck130@126.com.
Shanghai Medical College of Fudan University · CNFudan University Shanghai Cancer Center · CNWeihai Chest Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectsTo evaluate prognostic factors and treatment outcomes of primary squamous cell carcinoma in thyroid (PSCCTh) over the past decades using a large national database.

methodsAll patients diagnosed with PSCCTh between 1973 and 2015 were identified with the Surveillance, Epidemiology, and End Results Program (SEER) 18-registry database. Relevant clinical data were collected, and prognostic factors of overall survival (OS) and disease-specific survival (DSS) were analyzed.

resultsThis cohort study included 242 patients, accounting for 0.12% of all primary thyroid carcinomas from 1973 to 2015 nationwide. Of the patients with PSCCTh, 75% were older than 60 years at diagnosis. Patient age older than 60 years (HR 2.242, 95% CI 1.367-3.676, P = 0.001) and a tumor size larger than or equal to 50 mm (HR 1.479, 95% CI 1.011-2.165, P = 0.044) were independent negative prognostic factors. The univariate analysis suggested that the morphological subtype (OS, P = 0.033; DSS, P = 0.048), clinical treatment modality (OS, P < 0.0001; DSS, P < 0.0001), and T stage (OS, P = 0.004; DSS, P = 0.001) were important predictive factors for OS and DSS. In contrast, gender, race, year of diagnosis, geographic location, N stage, and M stage were not prognostic factors.

conclusionsPSCCTh is a rare malignancy with an aggressive nature and poor prognosis. Survival is predicted by the treatment modality, patient age, T stage, tumor size, and morphological subtypes. This study showed that early diagnosis and complete surgical resection plus adjuvant radiation therapy were associated with a better outcome.

Indexed as

AdultAgedCarcinoma, Squamous CellCohort StudiesFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm StagingPrognosisRegistriesRisk FactorsSEER ProgramThyroid NeoplasmsTreatment Outcome

Identifiers

PMID30719559
OpenAlexW2913430943

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.