SynthesisChiropractic & manual therapies2019
Manipulation-induced hypoalgesia in musculoskeletal pain populations: a systematic critical review and meta-analysis.
Synthesis in Chiropractic & manual therapies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The assistive gait devices and their implementation in activities of daily living for patients with neuromuscular disease: A systematic review and meta-analysis.Journal of neuromuscular diseases · 2026Pooled it
- Does manual therapy meaningfully change quantitative sensory testing and patient reported outcome measures in patients with musculoskeletal impairments related to the spine?: A 'trustworthy' systematic review and meta-analysis.The Journal of manual & manipulative therapy · 2024Pooled it
- An overview of systematic reviews examining the quantitative sensory testing-derived hypoalgesic effects of manual therapy for musculoskeletal pain.The Journal of manual & manipulative therapy · 2024Pooled it
- Verbal framing, rather than measured cognitive-affective variables, is associated with short-term outcomes after spinal manipulation: a secondary analysis of a randomized controlled trial.Pain management · 2026Trial
- One spinal manipulation session reduces local pain sensitivity but does not affect postural stability in individuals with chronic low back pain: a randomised, placebo-controlled trial.Chiropractic & manual therapies · 2024Trial
- Effects of Instrumental, Manipulative and Soft Tissue Approaches for the Suboccipital Region in Subjects with Chronic Mechanical Neck Pain. A Randomized Controlled Trial.International journal of environmental research and public health · 2021Trial
- Spinal manipulation and modulation of pain sensitivity in persistent low back pain: a secondary cluster analysis of a randomized trial.Chiropractic & manual therapies · 2021Trial
- Changes in pain sensitivity and spinal stiffness in relation to responder status following spinal manipulative therapy in chronic low Back pain: a secondary explorative analysis of a randomized trial.BMC musculoskeletal disorders · 2021Trial
- The effect on clinical outcomes when targeting spinal manipulation at stiffness or pain sensitivity: a randomized trial.Scientific reports · 2020Trial
- Pressure pain threshold and temporal summation in adults with episodic and persistent low back pain trajectories: a secondary analysis at baseline and after lumbar manipulation or sham.Chiropractic & manual therapies · 2020Trial
- Immediate effects of a lumbar spine manipulation on pain sensitivity and postural control in individuals with nonspecific low back pain: a randomized controlled trial.Chiropractic & manual therapies · 2020Trial
- What is the effect of spinal manipulation on the pressure pain threshold in young, asymptomatic subjects? A randomized placebo-controlled trial, with a cross-over design.Chiropractic & manual therapies · 2020Trial
- Mechanistic Explanations of Manual Therapy Do Not Influence Outcomes in Healthy Individuals: A Randomized Controlled Trial.Health science reports · 2026Article
- Waste not, want not: call to action for spinal manipulative therapy researchers.Chiropractic & manual therapies · 2024Article
- Restoration of normal central pain processing following manual therapy in nonspecific chronic neck pain.PloS one · 2024Article
- The Neurophysiological Lesion: A Scoping Review.Journal of chiropractic medicine · 2023Article
- Pressure pain thresholds in a real-world chiropractic setting: topography, changes after treatment, and clinical relevance?Chiropractic & manual therapies · 2022Article
- Time to evolve: the applicability of pain phenotyping in manual therapy.The Journal of manual & manipulative therapy · 2022Article
- Chiropractic Spinal Manipulation Prevents Secondary Hyperalgesia Induced by Topical Capsaicin in Healthy Individuals.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Impact of nonsurgical spinal decompression on paraspinal muscle morphology and mechanical properties in young adults with low back pain.The Journal of international medical research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Manipulation-induced hypoalgesia (MIH) represents reduced pain sensitivity following joint manipulation, and has been documented in various populations. It is unknown, however, whether MIH following high-velocity low-amplitude spinal manipulative therapy is a specific and clinically relevant treatment effect. Methods: This systematic critical review with meta-analysis investigated changes in quantitative sensory testing measures following high-velocity low-amplitude spinal manipulative therapy in musculoskeletal pain populations, in randomised controlled trials. Our objectives were to compare changes in quantitative sensory testing outcomes after spinal manipulative therapy vs. sham, control and active interventions, to estimate the magnitude of change over time, and to determine whether changes are systemic or not. Results: Fifteen studies were included. Thirteen measured pressure pain threshold, and four of these were sham-controlled. Change in pressure pain threshold after spinal manipulative therapy compared to sham revealed no significant difference. Pressure pain threshold increased significantly over time after spinal manipulative therapy (0.32 kg/cm Conclusions: We found that systemic MIH (for pressure pain threshold) does occur in musculoskeletal pain populations, though there was low quality evidence of no significant difference compared to sham manipulation. Future research should focus on the clinical relevance of MIH, and different types of quantitative sensory tests. Trial registration: Prospectively registered with PROSPERO (registration CRD42016041963).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.