Evidence map›Paper›PMID 30719216›Full record

ReviewOncotarget2019

Circulating mediators of remote ischemic preconditioning: search for the missing link between non-lethal ischemia and cardioprotection.

Muntasir Billah, Anisyah Ridiandries, Usaid Allahwala, Harshini Mudaliar, Anthony Dona, Stephen Hunyor, Levon M Khachigian, Ravinay Bhindi

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07118410 (Effect of Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07118410 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction

TypeinterventionalSponsorCentre Hospitalier Universitaire de NīmesRan2025 to 2027Enrolled38ConditionsHeart Failure, Ventricular Function, LeftArmsApplication of a vascular restriction device during resistance training
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Muntasir BillahDepartment of Cardiology, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Anisyah RidiandriesDepartment of Cardiology, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Usaid AllahwalaSydney Medical School Northern, University of Sydney, Sydney, NSW, Australia.
Harshini MudaliarDepartment of Cardiology, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Anthony DonaDepartment of Cardiology, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Stephen HunyorDepartment of Cardiology, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Levon M KhachigianVascular Biology and Translational Research, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Ravinay BhindiDepartment of Cardiology, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Northern Sydney Local Health District · AUUniversity of Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myocardial infarction (AMI) is one of the leading causes of mortality and morbidity worldwide. There has been an extensive search for cardioprotective therapies to reduce myocardial ischemia-reperfusion (I/R) injury. Remote ischemic preconditioning (RIPC) is a phenomenon that relies on the body's endogenous protective modalities against I/R injury. In RIPC, non-lethal brief I/R of one organ or tissue confers protection against subsequent lethal I/R injury in an organ remote to the briefly ischemic organ or tissue. Initially it was believed to be limited to direct myocardial protection, however it soon became apparent that RIPC applied to other organs such as kidney, liver, intestine, skeletal muscle can reduce myocardial infarct size. Intriguing discoveries have been made in extending the concept of RIPC to other organs than the heart. Over the years, the underlying mechanisms of RIPC have been widely sought and discussed. The involvement of blood-borne factors as mediators of RIPC has been suggested by a number of research groups. The main purpose of this review article is to summarize the possible circulating mediators of RIPC, and recent studies to establish the clinical efficacy of these mediators in cardioprotection from lethal I/R injury.

Indexed as

cardioprotectioncirculating mediatorsischemia-reperfusionmyocardial infarctionremote preconditioning

Identifiers

PMID30719216
PMCPMC6349428
OpenAlexW2907775851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.