Evidence map›Paper›PMID 30718983›Full record

ArticleNuclear receptor signaling2018

GR Utilizes a Co-Chaperone Cytoplasmic CAR Retention Protein to Form an N/C Interaction.

Marumi Ohno, Masahiko Negishi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear receptor signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Marumi OhnoNational Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Masahiko NegishiNational Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
National Institute of Environmental Health Sciences · USTriangle · US

Funding

Mechanisms and biological consequences of the nuclear receptor CAR activationZIAES080040 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI NEGISHI, MASAHIKO · 2009 to 2020
$35.3M
6 · The paper itself

Abstract

The N-terminal domain (NTD) of nuclear receptor superfamily members has been recently reported to regulate functions of the receptor through the interaction between the NTD and the C-terminal ligand binding domain (LBD), so-called an N/C interaction. Although this N/C interaction has been demonstrated in various nuclear receptors, eg, androgen receptor, this concept has not been observed in glucocorticoid receptor (GR). We hypothesized that GR requires its co-chaperone CCRP (cytoplasmic constitutive active/androstane receptor retention protein) to form a stable N/C interaction. This hypothesis was examined by co-immunoprecipitation assays using GR fragments overexpressing COS-1 cell lysate. Here, we demonstrated that GR undergoes the N/C interaction between the

Indexed as

Amino Acid SequenceAnimalsChlorocebus aethiopsConstitutive Androstane ReceptorCOS CellsCytoplasmHumansProtein BindingProtein DomainsProtein TransportReceptors, Cytoplasmic and NuclearReceptors, GlucocorticoidConstitutive Androstane ReceptorReceptors, Cytoplasmic and NuclearReceptors, GlucocorticoidCCRPGRN/C interaction

Identifiers

PMID30718983
PMCPMC6348740
OpenAlexW2905755607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.