Evidence map›Paper›PMID 30718804›Full record

ArticleEuropean journal of clinical nutrition2019

Soy intake and vasomotor menopausal symptoms among midlife women: a pooled analysis of five studies from the InterLACE consortium.

Yashvee Dunneram, Hsin-Fang Chung, Janet E Cade, Darren C Greenwood, Annette J Dobson, Ellen S Mitchell, Nancy F Woods, Eric J Brunner, Toyoko Yoshizawa, Debra Anderson and 1 more

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Article in European journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yashvee DunneramNutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK. fsyd@leeds.ac.uk.ORCID http://orcid.org/0000-0002-1012-7350
Hsin-Fang ChungSchool of Public Health, The University of Queensland, Brisbane, Queensland, Australia.
Janet E CadeNutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK.
Darren C GreenwoodNutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0001-7035-3096
Annette J DobsonSchool of Public Health, The University of Queensland, Brisbane, Queensland, Australia.
Ellen S MitchellFamily and Child Nursing, School of Nursing, University of Washington, Seattle, WA, USA.
Nancy F WoodsBiobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Seattle, WA, USA.
Eric J BrunnerDepartment of Epidemiology and Public Health, University College London, London, UK.
Toyoko YoshizawaDepartment of Women's Health Nursing, Tohoku University Graduate School of Medicine, Sendai, Japan.
Debra AndersonMenzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.
Gita D MishraSchool of Public Health, The University of Queensland, Brisbane, Queensland, Australia.

Funding

British Heart Foundation RG/16/11/32334
6 · The paper itself

Abstract

BACKGROUND/

objectivesPhytoestrogen rich-foods such as soy may be associated with less frequent/severe vasomotor menopausal symptoms (VMS), although evidence is limited. We thus investigated the associations between the consumption of soy products and soy milk and the frequency/severity of VMS. SUBJECTS/

methodsWe pooled data from 19,351 middle-aged women from five observational studies in Australia, UK, USA, and Japan that contribute to the International Collaboration for a Life course Approach to reproductive health and Chronic disease Events (InterLACE). Information on soy consumption, VMS and covariates were collected by self-report. We included 11,006 women who had complete data on soy consumption, VMS and covariates at baseline for the cross-sectional analysis. For the prospective analysis, 4522 women who were free of VMS at baseline and had complete data on VMS at follow-up were considered. Multinomial logistic regression and binary logistic regression models were used.

resultsNo statistically significant evidence of an association was found between soy products (relative risk ratio (RRR): 0.92, 95% CI: 0.76-1.11) or soy milk (RRR: 1.24, 95% CI: 0.93-1.65) and the likelihood of reporting frequent or severe VMS cross-sectionally. Prospective results indicated that frequent consumption of soy products (odds ratio (OR): 0.63, 95% CI: 0.45-0.89) but not soy milk (OR: 1.11, 95% CI: 0.85-1.45) was associated with lower likelihood of reporting subsequent VMS, after adjustment for socio-demographic and reproductive factors.

conclusionsThese are the first ever findings from pooled observational data of association between consumption of soy products and VMS.

Indexed as

Cross-Sectional StudiesDietFemaleHot FlashesHumansMenopauseMiddle AgedPhytoestrogensSoy FoodsPhytoestrogens

Identifiers

PMID30718804

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.