ArticleScientific reports2019
A strategy for qualitative and quantitative profiling of glycyrrhiza extract and discovery of potential markers by fingerprint-activity relationship modeling.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Evaluating the quality consistency of antiviral oral liquid by high-performance liquid chromatography five-wavelength matched average fusion fingerprint combined with electrochemical fingerprint and ultraviolet spectral quantum fingerprint.Journal of chromatography. A · 2023Article
- Biological Screening ofPharmaceuticals (Basel, Switzerland) · 2022Article
- The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions.Phytomedicine plus : international journal of phytotherapy and phytopharmacology · 2021Review
- Identification of geographical origins of Panax notoginseng based on HPLC multi-wavelength fusion profiling combined with average linear quantitative fingerprint method.Scientific reports · 2021Article
- Quality Evaluation ofJournal of analytical methods in chemistry · 2021Article
- A strategy for quality evaluation of salt-treated Apocyni Veneti Folium and discovery of efficacy-associated markers by fingerprint-activity relationship modeling.Scientific reports · 2019Article
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Authors and funding
4 authors.
Funding
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Abstract
This study was to evaluate the quality consistency of glycyrrhiza extract and to explore the possible anti-oxidant components in combination with chromatographic fingerprint and bioactivity evaluation. Characteristic fingerprints of glycyrrhiza extract samples from different sources were generated by high performance liquid chromatography with diode array detector (HPLC-DAD) and evaluated using hierarchical clustering and similarity analysis. Compared with the conventional qualitative similarity evaluation method, the averagely linear quantified fingerprint method had an important quantitative similarity parameter supported by quantitative analysis, which was recommended in the fingerprint evaluation. Antioxidant activities of the glycyrrhiza extract samples were determined by DPPH (2, 2-diphenyl-1-picryldrazyl) radical scavenging assays. In addition, the fingerprint-efficacy relationship was investigated by the chemical fingerprints and the anti-oxidant activities utilizing partial least squares model, which was capable of exploring and discovering the bioactive components of glycyrrhiza extracts. Therefore, the present study provided a powerful strategy to evaluate the holistic quality consistency of medicinal plant.
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