ArticleScientific reports2019
Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 55 citations in OpenAlex.
- Modification of Porous Silicon with an Amphiphilic Quaternary Ammonium Hydrocarbon for Nanomedicine Applications.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Theoretical analysis of MOFs for pharmaceutical applications by using machine learning models to predict loading capacity and cell viability.Scientific reports · 2025Article
- Evaluation of the synergistic effects of curcumin-resveratrol co-loaded biogenic silica on colorectal cancer cells.Frontiers in pharmacology · 2024Article
- A Sensitive Hydroquinone Amperometric Sensor Based on a Novel Palladium Nanoparticle/Porous Silicon/Polypyrrole-Carbon Black Nanocomposite.Biosensors · 2023Article
- Porous Silicon Nanocarriers with Stimulus-Cleavable Linkers for Effective Cancer Therapy.Advanced healthcare materials · 2022Article
- Recent Developments in Porous Silicon Nanovectors with Various Imaging Modalities in the Framework of Theranostics.ChemMedChem · 2022Review
- EGDMA- and TRIM-Based Microparticles Imprinted with 5-Fluorouracil for Prolonged Drug Delivery.Polymers · 2022Article
- PLLA Coating of Active Implants for Dual Drug Release.Molecules (Basel, Switzerland) · 2022Article
- Recent advances in hybrid system of porous silicon nanoparticles and biocompatible polymers for biomedical applications.Biomedical engineering letters · 2021Review
- Engineering the Interface between Inorganic Nanoparticles and Biological Systems through Ligand Design.Nanomaterials (Basel, Switzerland) · 2021Review
- High-Throughput Tailoring of Nanocellulose Films: From Complex Bio-Based Materials to Defined Multifunctional Architectures.ACS applied bio materials · 2020Article
- Article
- Surface Heterogeneous Nucleation-Mediated Release of Beta-Carotene from Porous Silicon.Nanomaterials (Basel, Switzerland) · 2020Article
- Crystallisation Behaviour of Pharmaceutical Compounds Confined within Mesoporous Silicon.Pharmaceutics · 2020Review
- Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy.International journal of nanomedicine · 2020Article
- Controlling and Predicting the Dissolution Kinetics of Thermally Oxidised Mesoporous Silicon Particles: Towards Improved Drug Delivery.Pharmaceutics · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi films were first modified with 1-dodecene. To further modify the external surface of the pSi samples, an interlayer was applied by silanization with (3-aminopropyl)triethoxysilane (APTES) following air plasma treatment. In addition, copolymers of N-(2-hydroxypropyl) acrylamide (HPAm) and N-benzophenone acrylamide (BPAm) were grafted onto the external pSi surfaces by spin-coating and UV crosslinking. Each modification step was verified using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, water contact angle (WCA) measurements, X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). In order to confirm that the air plasma treatment and silanization step only occurred on the top surface of pSi samples, confocal microscopy was employed after fluorescein isothiocyanate (FITC) conjugation. Drug release studies carried out over 17 h in PBS demonstrated that the modified pSi reservoirs released CPT continuously, while showing excellent stability. Furthermore, protein adsorption and cell attachment studies demonstrated the ability of the graft polymer layer to reduce both significantly. In combination with the biocompatible pSi substrate material, the facile modification strategy described in this study provides access to new multifunctional drug delivery systems (DDS) for applications in cancer therapy.
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