ArticleScientific reports2019
Combining MALDI-TOF and genomics in the study of methicillin resistant and multidrug resistant Staphylococcus pseudintermedius in New Zealand.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Genotypic diversity and genotype-phenotype concordance of antimicrobial resistance in methicillin-resistant staphylococci from dogs and cats.Veterinary and animal science · 2026Article
- Longitudinal survey investigating vectors and reservoirs forApplied and environmental microbiology · 2025Article
- Loop-mediated isothermal amplification assay coupled with lateral flow dipstick for the rapid detection of methicillin-resistant Staphylococcus pseudintermedius from dogs.Veterinary research communications · 2025Article
- Multi-label classification to predict antibiotic resistance from raw clinical MALDI-TOF mass spectrometry data.Scientific reports · 2024Article
- Methicillin-resistant Staphylococcus pseudintermedius: epidemiological changes, antibiotic resistance, and alternative therapeutic strategies.Veterinary research communications · 2024Review
- Diagnostic and commensal Staphylococcus pseudintermedius genomes reveal niche adaptation through parallel selection of defense mechanisms.Nature communications · 2023Article
- Antimicrobial ResistantPathogens (Basel, Switzerland) · 2023Article
- First report of Staphylococcus pseudintermedius ST71-SCCmec III and ST45-ΨSCCmecBMC research notes · 2023Article
- Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry in veterinary medicine: Recent advances (2019-present).Veterinary world · 2022Review
- A Retrospective Study of Antimicrobial Resistant Bacteria Associated with Feline and Canine Urinary Tract Infection in Hong Kong SAR, China-A Case Study on Implication of First-Line Antibiotics Use.Antibiotics (Basel, Switzerland) · 2022Article
- Utility and Applicability of Rapid Diagnostic Testing in Antimicrobial Stewardship in the Asia-Pacific Region: A Delphi Consensus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Antimicrobial Resistance in New Zealand-A One Health Perspective.Antibiotics (Basel, Switzerland) · 2022Review
- Prevalence, Mechanism, Genetic Diversity, and Cross-Resistance Patterns of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Occurrence and characterization of methicillin-resistant Staphylococcus spp. in diseased dogs in Brazil.PloS one · 2022Article
- Accessory Genome Dynamics of Local and GlobalFrontiers in microbiology · 2022Article
- Absence of Host-Specific Genes in Canine and HumanAntibiotics (Basel, Switzerland) · 2021Article
- Phylogenomic Characterization of a NovelmSystems · 2021Article
- Antibiotic Resistance Profile and Biofilm Production ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis.PLoS computational biology · 2021Article
- Rapid Methods for Antimicrobial Resistance Diagnostics.Antibiotics (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus pseudintermedius is an opportunistic and emerging zoonotic pathogen that primarily colonises the skin of dogs. Many common variants are methicillin resistant (MRSP) or multidrug resistant (MDR), and drug resistance is increasingly reported across the globe. In New Zealand, MRSP isolation remains rare in clinics. To pre-emptively inform diagnostic and antimicrobial stewardship practices, we examine isolates of S. pseudintermedius, MRSP and MDR-MRSP from New Zealand dogs using a combination of methodologies. Genetic and genomic data combined with antimicrobial susceptibility screening identify common drug-resistance profiles and their genetic determinants. We demonstrate that sensitive and specific species-level identification of S. pseudintermedius can be achieved using Bruker MALDI-TOF MS and, further, that this technique can be used to identify some common subtype variants, providing a level of categorical precision that falls somewhere between single-locus and multi-locus sequence typing. Comparative genomics analysis of global S. pseudintermedius data shows that MRSP moves frequently across the globe, but that horizontal gene transfer events resulting in the acquisition of the SCCmec cassette (responsible for beta-lactam antibiotic resistance) are infrequent. This suggests that biosecurity and surveillance in addition to antibiotic stewardship should play important roles in mitigating the risk of MRSP, especially in countries such as New Zealand where MRSP is still rare.
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