ArticleScientific reports2019
Interactions within the microbiome alter microbial interactions with host chemical defences and affect disease in a marine holobiont.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Standardized 16S Meta-Analysis Reveals Consistent Host-Associated Patterns in Laminariales Epiphytic Microbiomes.MicrobiologyOpen · 2026Pooled it
- Not All Children Are the Same: Differences in the Microbiome Assembly During Early Development of Seaweeds.Environmental microbiology · 2026Article
- Effects of Extreme Rainfall on a Dominant Seaweed Are Mitigated by Its Microbiota.Ecology and evolution · 2026Article
- Examining Short Temporal Changes in Intertidal Macroalgal Microbiomes at 'Ewa Beach, O'Ahu, Hawai'i: Some Hosts Varied While Others Remained Stable.Environmental microbiology reports · 2026Article
- Plant viruses and the microbiome: a complex network shaping plant health and disease resistance.Archives of virology · 2026Review
- Seasonal Cycles in a Seaweed Holobiont: A Multiyear Time Series Reveals Repetitive Microbial Shifts and Core Taxa.Environmental microbiology · 2025Article
- A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean.Communications biology · 2025Review
- Active fungal infections alter the respiratory microbiome profiles of Mayo Clinic Arizona patients.Frontiers in microbiomes · 2025Article
- Reciprocal transplantation experiments reveal local adaptation of seaweed-associated bacteria.ISME communications · 2025Article
- Potential role of alginate in marine bacteria-yeast interactions.Applied and environmental microbiology · 2024Article
- Article
- Evolutionary modeling suggests that addictions may be driven by competition-induced microbiome dysbiosis.Communications biology · 2023Article
- Article
- The Gill Microbiota ofMicroorganisms · 2022Article
- Host genetics, phenotype and geography structure the microbiome of a foundational seaweed.Molecular ecology · 2022Article
- Shifting chemical defence or novel weapons? A review of defence traits inMarine life science & technology · 2022Review
- Bacterial controlled mitigation of dysbiosis in a seaweed disease.The ISME journal · 2022Article
- Review
- Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our understanding of diseases has been transformed by the realisation that people are holobionts, comprised of a host and its associated microbiome(s). Disease can also have devastating effects on populations of marine organisms, including dominant habitat formers such as seaweed holobionts. However, we know very little about how interactions between microorganisms within microbiomes - of humans or marine organisms - affect host health and there is no underpinning theoretical framework for exploring this. We applied ecological models of succession to bacterial communities to understand how interactions within a seaweed microbiome affect the host. We observed succession of surface microbiomes on the red seaweed Delisea pulchra in situ, following a disturbance, with communities 'recovering' to resemble undisturbed states after only 12 days. Further, if this recovery was perturbed, a bleaching disease previously described for this seaweed developed. Early successional strains of bacteria protected the host from colonisation by a pathogenic, later successional strain. Host chemical defences also prevented disease, such that within-microbiome interactions were most important when the host's chemical defences were inhibited. This is the first experimental evidence that interactions within microbiomes have important implications for host health and disease in a dominant marine habitat-forming organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.