ArticleScientific reports2019
Diversified secondary metabolite biosynthesis gene repertoire revealed in symbiotic dinoflagellates.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Bioactivity and Biotechnological Overview of Naturally Occurring Compounds from the Dinoflagellate Family Symbiodiniaceae: A Systematic Review.TheScientificWorldJournal · 2021Pooled it
- Transcriptomic insights into polyketides and toxin biosynthesis genes in freshwater dinoflagellates.Scientific reports · 2026Article
- RNA-Binding Proteins in Dinoflagellates.International journal of molecular sciences · 2026Review
- Review
- The genome of antibiotic-producing colonies of the Pelagophyte alga Chrysophaeum taylorii reveals a diverse and non-canonical capacity for secondary metabolism.Scientific reports · 2023Article
- Dinoflagellate Phosphopantetheinyl Transferase (PPTase) and Thiolation Domain Interactions Characterized Using a Modified Indigoidine Synthesizing Reporter.Microorganisms · 2022Article
- Unveiling the genomic potential ofMicrobial genomics · 2022Article
- Salvaging high-quality genomes of microbial species from a meromictic lake using a hybrid sequencing approach.Communications biology · 2021Article
- A New Dinoflagellate Genome Illuminates a Conserved Gene Cluster Involved in Sunscreen Biosynthesis.Genome biology and evolution · 2021Article
- Natural Products as Potential Antiviral Drugs: The Specific Case of Marine Biotoxins.Russian journal of bioorganic chemistry · 2021Article
- A Global Approach to Estimating the Abundance and Duplication of Polyketide Synthase Domains in Dinoflagellates.Evolutionary bioinformatics online · 2021Article
- Response of Coral Reef Dinoflagellates to Nanoplastics under Experimental Conditions Suggests Downregulation of Cellular Metabolism.Microorganisms · 2020Article
- Integrated omics unveil the secondary metabolic landscape of a basal dinoflagellate.BMC biology · 2020Article
- Article
- The Genetic Basis of Toxin Biosynthesis in Dinoflagellates.Microorganisms · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symbiodiniaceae dinoflagellates possess smaller nuclear genomes than other dinoflagellates and produce structurally specialized, biologically active, secondary metabolites. Till date, little is known about the evolution of secondary metabolism in dinoflagellates as comparative genomic approaches have been hampered by their large genome sizes. Here, we overcome this challenge by combining genomic and metabolomics approaches to investigate how chemical diversity arises in three decoded Symbiodiniaceae genomes (clades A3, B1 and C). Our analyses identify extensive diversification of polyketide synthase and non-ribosomal peptide synthetase genes from two newly decoded genomes of Symbiodinium tridacnidorum (A3) and Cladocopium sp. (C). Phylogenetic analyses indicate that almost all the gene families are derived from lineage-specific gene duplications in all three clades, suggesting divergence for environmental adaptation. Few metabolic pathways are conserved among the three clades and we detect metabolic similarity only in the recently diverged clades, B1 and C. We establish that secondary metabolism protein architecture guides substrate specificity and that gene duplication and domain shuffling have resulted in diversification of secondary metabolism genes.
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