ArticleTranslational psychiatry2019
Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.
Open access · goldAbstract read
In one paragraph
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Acute orexin antagonism selectively modulates anticipatory anxiety in humans: implications for addiction and anxiety.Translational psychiatry · 2022Trial
- First-in-human study with ACT-539313, a novel selective orexin-1 receptor antagonist.British journal of clinical pharmacology · 2020Trial
- Dynamics of Fear-Generalization Processes and Their Predictive Value for the Development of Anxiety-Related Psychopathology in Adolescents and Adults: A Study Protocol for a Longitudinal Study.International journal of methods in psychiatric research · 2026Article
- Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression?Journal of sleep research · 2025Review
- The role of the orexin system in the neurobiology of anxiety disorders: Potential for a novel treatment target.Neuroscience applied · 2024Review
- Estrogens, age, and, neonatal stress: panic disorders and novel views on the contribution of non-medullary structures to respiratory control and COFrontiers in physiology · 2023Review
- COBMC psychiatry · 2022Article
- Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone.Brain sciences · 2022Review
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function.Frontiers in aging neuroscience · 2022Article
- The role of basolateral amygdala orexin 1 receptors on the modulation of pain and psychosocial deficits in nitroglycerin-induced migraine model in adult male rats.The Korean journal of pain · 2022Article
- Experimental Drugs for Panic Disorder: An Updated Systematic Review.Journal of experimental pharmacology · 2021Review
- Hypocretin (Orexin) Replacement Therapies.Medicine in drug discovery · 2020Article
- Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders.Neuroscience bulletin · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 16 institutions in 3 countries.
Michael G GottschalkDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jan RichterDepartment of Biological and Clinical Psychology/Psychotherapy, University of Greifswald, Greifswald, Germany.
Christiane ZieglerDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-8543-2010
Miriam A SchieleDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Julia MannDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Maximilian J GeigerDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Christoph SchartnerDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-0599-3956
György A HomolaDepartment of Neuroradiology, University of Würzburg, Würzburg, Germany.
Georg W AlpersDepartment of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Christian BüchelDepartment of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lydia FehmDepartment of Psychology, Humboldt University, Berlin, Germany.
Thomas FydrichDepartment of Psychology, Humboldt University, Berlin, Germany.
Alexander L GerlachDepartment of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-6794-5349
Andrew T GlosterDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Sylvia Helbig-LangDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Raffael KalischNeuroimaging Center (NIC) und Deutsches Resilienz-Zentrum (DRZ), Johannes Gutenberg University Medical Center, Mainz, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Thomas LangDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Tina B LonsdorfDepartment of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christiane A Pané-FarréDepartment of Biological and Clinical Psychology/Psychotherapy, University of Greifswald, Greifswald, Germany.
Andreas StröhleDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Heike WeberDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-9421-1292
Peter ZwanzgerDepartment of Psychiatry and Psychotherapy, University Hospital of Münster, Münster, Germany.
Volker AroltDepartment of Psychiatry and Psychotherapy, University Hospital of Münster, Münster, Germany.
Marcel RomanosDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Hans-Ulrich WittchenDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Alfons HammDepartment of Biological and Clinical Psychology/Psychotherapy, University of Greifswald, Greifswald, Germany.
Paul PauliDepartment of Psychology, Center of Mental Health, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-0692-6720
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital of Frankfurt, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-0992-634X
Jürgen DeckertDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Susanne NeufangDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Michael HöflerDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Katharina DomschkeDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. katharina.domschke@uniklinik-freiburg.de.
University of Freiburg · DEUniversitätsklinikum Würzburg · DEHumboldt-Universität zu Berlin · DEUniversität Greifswald · DEUniversität Hamburg · DEGoethe University Frankfurt · DETechnische Universität Dresden · DEUniversity Hospital Münster · DEUniversity of Würzburg · DEDornier Flugzeugwerke (Germany) · DEJohannes Gutenberg University Mainz · DEPhilipps University of Marburg · DEUniversity of Basel · CHUniversity of California, San Francisco · USUniversity of Cologne · DEUniversity of Mannheim · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preclinical studies point to a pivotal role of the orexin 1 (OX
Indexed as
AgoraphobiaCognitive Behavioral TherapyOutcome Assessment, Health CarePanic DisorderAdultAvoidance LearningCase-Control StudiesCerebrumFearFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOrexin ReceptorsPhenotypeHCRTR1 protein, humanOrexin Receptors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.