ArticleScientific reports2019
Structural and biochemical insight into mode of action and subsite specificity of a chitosan degrading enzyme from Bacillus spec. MN.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- In Silico Study of Potential Binding Sites of the Family GH126 Enzyme CPF_2247 fromMolecules (Basel, Switzerland) · 2026Article
- Comparative Potential of Chitinase and Chitosanase from the StrainBiotech (Basel (Switzerland)) · 2025Article
- Fast insights into chitosan-cleaving enzymes by simultaneous analysis of polymers and oligomers through size exclusion chromatography.Scientific reports · 2024Article
- A Computational Biology Study on the Structure and Dynamics Determinants of Thermal Stability of the Chitosanase fromInternational journal of molecular sciences · 2023Article
- Deciphering the ChitoCode: fungal chitins and chitosans as functional biopolymers.Fungal biology and biotechnology · 2021Article
- Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization.Polymers · 2021Review
- Biochemical characterization of a novel bifunctional chitosanase from Paenibacillus barengoltzii for chitooligosaccharide production.World journal of microbiology & biotechnology · 2021Article
- Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach-A Novel and Potential Antibacterial Formulation.Pharmaceutics · 2020Article
- Rational protein design ofJournal of biological engineering · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chitosans, partially de-N-acetylated derivatives of chitin, are multifunctional biopolymers. In nature, biological activities of partially acetylated chitosan polymers are mediated in part by their oligomeric breakdown products, which are generated in situ by the action of chitosanolytic enzymes. Understanding chitosanolytic enzymes, therefore, can lead to the production of chitosan oligomers with fully defined structures that may confer specific bioactivities. To address whether defined oligomer products can be produced via chitosanolytic enzymes, we here characterized a GH8 family chitosanase from Bacillus spec. MN, determining its mode of action and product profiles. We found that the enzyme has higher activity towards polymers with lower degree of acetylation. Oligomeric products were dominated by GlcN
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