Evidence map›Paper›PMID 30718496›Full record

ArticleNature communications2019

Just add sugar for carbohydrate induced self-assembly of curcumin.

Sandy Wong, Jiacheng Zhao, Cheng Cao, Chin Ken Wong, Rhiannon P Kuchel, Sergio De Luca, James M Hook, Christopher J Garvey, Sean Smith, Junming Ho and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 89 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Natural Products from Herbal Medicine Self-Assemble into Advanced Bioactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. A Colorimetric AgNanomaterials (Basel, Switzerland) · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sandy WongSchool of Chemistry, Centre for Advanced Macromolecular Design (CAMD), University of New South Wales, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0003-2319-0911
Jiacheng ZhaoSchool of Chemistry, Centre for Advanced Macromolecular Design (CAMD), University of New South Wales, Sydney, NSW, 2052, Australia.
Cheng CaoSchool of Chemistry, Centre for Advanced Macromolecular Design (CAMD), University of New South Wales, Sydney, NSW, 2052, Australia.
Chin Ken WongSchool of Chemistry, Centre for Advanced Macromolecular Design (CAMD), University of New South Wales, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0003-3040-4412
Rhiannon P KuchelMark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, 2052, Australia.
Sergio De LucaSchool of Chemical Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
James M HookSchool of Chemistry, Centre for Advanced Macromolecular Design (CAMD), University of New South Wales, Sydney, NSW, 2052, Australia.
Christopher J GarveyAustralian Centre for Neutron Scattering, ANSTO, Lucas Heights, NSW, 2234, Australia.
Sean SmithSchool of Chemical Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
Junming HoSchool of Chemistry, Centre for Advanced Macromolecular Design (CAMD), University of New South Wales, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0001-9381-924X
Martina H StenzelSchool of Chemistry, Centre for Advanced Macromolecular Design (CAMD), University of New South Wales, Sydney, NSW, 2052, Australia. m.stenzel@unsw.edu.au.ORCID http://orcid.org/0000-0002-6433-4419
UNSW Sydney · AUAustralian National University · AUAustralian Nuclear Science and Technology Organisation · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In nature, self-assembly processes based on amphiphilic molecules play an integral part in the design of structures of higher order such as cells. Among them, amphiphilic glycoproteins or glycolipids take on a pivotal role due to their bioactivity. Here we show that sugars, in particular, fructose, are capable of directing the self-assembly of highly insoluble curcumin resulting in the formation of well-defined capsules based on non-covalent forces. Simply by mixing an aqueous solution of fructose and curcumin in an open vessel leads to the generation of capsules with sizes ranging between 100 and 150 nm independent of the initial concentrations used. Our results demonstrate that hydrogen bonding displayed by fructose can induce the self-assembly of hydrophobic molecules such as curcumin into well-ordered structures, and serving as a simple and virtually instantaneous way of making nanoparticles from curcumin in water with the potential for template polymerization and nanocarriers.

Indexed as

CurcuminDrug CarriersFructoseHydrogen BondingHydrophobic and Hydrophilic InteractionsNanoparticlesSugarsCurcuminDrug CarriersFructoseSugars

Identifiers

PMID30718496
PMCPMC6362107
OpenAlexW2914253678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.