ArticleTranslational psychiatry2019
Dynamic expression of genes associated with schizophrenia and bipolar disorder across development.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance.bioRxiv : the preprint server for biology · 2026Article
- Genetic and neuroanatomical correlates of bipolar disorder in high-risk youth.BMJ mental health · 2026Article
- Effects of Shared and Nonshared Schizophrenia and Bipolar Disorder Alleles on Cognition and Educational Attainment in the UK Biobank.Biological psychiatry global open science · 2025Article
- Engineered serum markers for non-invasive monitoring of gene expression in the brain.Nature biotechnology · 2024Article
- Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice.Translational psychiatry · 2024Article
- The contribution of silencer variants to human diseases.Genome biology · 2024Article
- Massively parallel characterization of regulatory elements in the developing human cortex.Science (New York, N.Y.) · 2024Article
- Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation.Schizophrenia bulletin · 2024Article
- Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour.PloS one · 2024Article
- Allele biased transcription factor binding across human brain regions gives mechanistic insight into eQTLs.bioRxiv : the preprint server for biology · 2023Article
- Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex.bioRxiv : the preprint server for biology · 2023Article
- Single-Nuclei RNA Sequencing of 5 Regions of the Human Prenatal Brain Implicates Developing Neuron Populations in Genetic Risk for Schizophrenia.Biological psychiatry · 2023Article
- Ultra-rare and common genetic variant analysis converge to implicate negative selection and neuronal processes in the aetiology of schizophrenia.Molecular psychiatry · 2022Article
- Schizophrenia Genomics: Convergence on Synaptic Development, Adult Synaptic Plasticity, or Both?Biological psychiatry · 2022Review
- Article
- Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity.Biological psychiatry · 2021Article
- Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- RCL1 copy number variants are associated with a range of neuropsychiatric phenotypes.Molecular psychiatry · 2021Article
- Article
- From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum.Frontiers in aging neuroscience · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Common genetic variation contributes a substantial proportion of risk for both schizophrenia and bipolar disorder. Furthermore, there is evidence of significant, but not complete, overlap in genetic risk between the two disorders. It has been hypothesised that genetic variants conferring risk for these disorders do so by influencing brain development, leading to the later emergence of symptoms. The comparative profile of risk gene expression for schizophrenia and bipolar disorder across development over different brain regions however remains unclear. Using genotypes derived from genome-wide associations studies of the largest available cohorts of patients and control subjects, we investigated whether genes enriched for schizophrenia and bipolar disorder association show a bias for expression across any of 13 developmental stages in prefrontal cortical and subcortical brain regions. We show that genetic association with schizophrenia is positively correlated with expression in the prefrontal cortex during early midfetal development and early infancy, and negatively correlated with expression during late childhood, which stabilises in adolescence. In contrast, risk-associated genes for bipolar disorder did not exhibit a bias towards expression at any prenatal stage, although the pattern of postnatal expression was similar to that of schizophrenia. These results highlight the dynamic expression of genes harbouring risk for schizophrenia and bipolar disorder across prefrontal cortex development and support the hypothesis that prenatal neurodevelopmental events are more strongly associated with schizophrenia than bipolar disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.