Trial reportTranslational psychiatry2019
Prefrontal networks dynamically related to recovery from major depressive disorder: a longitudinal pharmacological fMRI study.
Trial report in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predicting treatment outcomes in major depressive disorder using brain magnetic resonance imaging: a meta-analysis.Molecular psychiatry · 2025Pooled it
- Magnetic resonance imaging for individual prediction of treatment response in major depressive disorder: a systematic review and meta-analysis.Translational psychiatry · 2021Pooled it
- Natural Language Processing Applied to Psychiatric Clinical Notes: Scoping Review.JMIR medical informatics · 2026Article
- Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non-Remission in Patients With Major Depressive Disorder.Depression and anxiety · 2026Article
- Early treatment-related changes in dorsolateral prefrontal cortex activity and functional connectivity as potential biomarkers for antidepressant response in major depressive disorder.Translational psychiatry · 2025Article
- Major depressive disorder is characterized by differential theta and alpha patterns during working memory updating.BMC psychiatry · 2025Article
- Spatiotemporal alterations of thalamo-cortical effective connectivity in major depressive disorder patients.BMC psychiatry · 2025Article
- TRPC4/5 inhibitors: Phase I results and proof of concept studies.European archives of psychiatry and clinical neuroscience · 2025Review
- The impact of mindfulness therapy combined with mentalization-based family therapy on suicidal ideation in adolescents with depressive disorder: randomized intervention study.Annals of general psychiatry · 2024Article
- Neural mechanisms of emotional health in traumatic brain injury patients undergoing rTMS treatment.Molecular psychiatry · 2023Article
- Trait- and state-like co-activation pattern dynamics in current and remitted major depressive disorder.Journal of affective disorders · 2023Article
- Aberrant Resting-State Functional Connectivity in MDD and the Antidepressant Treatment Effect-A 6-Month Follow-Up Study.Brain sciences · 2023Article
- Altered patterns of central executive, default mode and salience network activity and connectivity are associated with current and future depression risk in two independent young adult samples.Molecular psychiatry · 2023Article
- Review: The use of functional magnetic resonance imaging (fMRI) in clinical trials and experimental research studies for depression.Frontiers in neuroimaging · 2023Review
- Indoleamine 2, 3-dioxygenase is responsible for low stress tolerance after intracerebral hemorrhage.PloS one · 2023Article
- Altered spatio-temporal state patterns for functional dynamics estimation in first-episode drug-naive major depression.Brain imaging and behavior · 2022Article
- Prediction of remission among patients with a major depressive disorder based on the resting-state functional connectivity of emotion regulation networks.Translational psychiatry · 2022Article
- Brain morphometry and connectivity differs between adolescent- and adult-onset major depressive disorder.Depression and anxiety · 2022Article
- Prefrontal cortex and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- tDCS over the left prefrontal Cortex improves mental flexibility and inhibition in geriatric inpatients with symptoms of depression or anxiety: A pilot randomized controlled trial.Frontiers in rehabilitation sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to lacking predictors of depression recovery, successful treatment of major depressive disorder (MDD) is frequently only achieved after therapeutic optimization leading to a prolonged suffering of patients. This study aimed to determine neural prognostic predictors identifying non-remitters prior or early after treatment initiation. Moreover, it intended to detect time-sensitive neural mediators indicating depression recovery. This longitudinal, interventional, single-arm, open-label, phase IV, pharmacological functional magnetic resonance imaging (fMRI) study comprised four scans at important stages prior (day 0) and after escitalopram treatment initiation (day 1, 28, and 56). Totally, 22 treatment-free MDD patients (age mean ± SD: 31.5 ± 7.7; females: 50%) suffering from a concurrent major depressive episode without any comorbid DSM-IV axis I diagnosis completed the study protocol. Primary outcome were neural prognostic predictors of depression recovery. Enhanced de-activation of anterior medial prefrontal cortex (amPFC, single neural mediator) indicated depression recovery correlating with MADRS score and working memory improvements. Strong dorsolateral PFC (dlPFC) activation and weak dlPFC-amPFC, dlPFC-posterior cingulate cortex (PCC), dlPFC-parietal lobe (PL) coupling (three prognostic predictors) hinted at depression recovery at day 0 and 1. Preresponse prediction of continuous (dlPFC-PL: R
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