ArticleTranslational psychiatry2019
Structural neuroimaging correlates of social deficits are similar in autism spectrum disorder and attention-deficit/hyperactivity disorder: analysis from the POND Network.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Evidence of emotion dysregulation as a core symptom of adult ADHD: A systematic review.PloS one · 2023Pooled it
- NeuroLangSeg: Language-Guided Subcortical Segmentation with Pseudo-Supervision and Anatomical-Linguistic Validation.Proceedings of machine learning research · 2026Article
- Identifying Neurodevelopmental Domain Subgroups in Autism and ADHD.Journal of autism and developmental disorders · 2026Article
- The prevalence of autism spectrum traits and autism spectrum disorders in children and adolescents with obsessive compulsive disorder: systematic review and meta-analysis.BJPsych open · 2026Review
- Connectome-based symptom mapping and in silico related gene expression in children with autism and/or attention-deficit/hyperactivity disorder.Molecular psychiatry · 2026Article
- Transdiagnostic Behavioral Phenotypes and Comorbid Gastrointestinal Symptoms in Neurodevelopmental Disorders: An Exploratory Study.Autism research : official journal of the International Society for Autism Research · 2026Article
- Longitudinal stability and Autism Diagnostic Observation Scale-2 predictors of the Childhood Joint Attention Rating Scale.Autism : the international journal of research and practice · 2025Article
- Gut microbiota and blood metabolites: unveiling their roles in hippocampal volume changes through Mendelian randomization and mediation analysis.Metabolic brain disease · 2025Article
- The Role of Physical Activity in ADHD Management: Diagnostic, Digital and Non-Digital Interventions, and Lifespan Considerations.Children (Basel, Switzerland) · 2025Review
- Behavioral synchronization of two individuals during cooperative interaction: the role of the mentalization ability as measured by the reading the mind in the eyes test.BMC psychology · 2025Article
- Hippocampal subfield and amygdala volumes are associated with difficulties in emotion regulation of depressed patients with a history of childhood maltreatment.Frontiers in psychiatry · 2025Article
- Connectome-based symptom mapping andmedRxiv : the preprint server for health sciences · 2024Article
- Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response.Neuroscience bulletin · 2024Article
- Controllability in attention deficit hyperactivity disorder brains.Cognitive neurodynamics · 2024Article
- The distribution of parent-reported attention-deficit/hyperactivity disorder and subclinical autistic traits in children with and without an ADHD diagnosis.JCPP advances · 2024Article
- MAPSeg: Unified Unsupervised Domain Adaptation for Heterogeneous Medical Image Segmentation Based on 3D Masked Autoencoding and Pseudo-Labeling.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2024Article
- Behaviour-correlated profiles of cerebellar-cerebral functional connectivity observed in independent neurodevelopmental disorder cohorts.Translational psychiatry · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Delineating a Pathway for the Discovery of Functional Connectome Biomarkers of Autism.Advances in neurobiology · 2024Review
- Assessment of anxiety in children with neurodevelopment disorders: Rasch analysis of the Spence Children's Anxiety Scale.Frontiers in psychiatry · 2024Article
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Authors and funding
16 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD) have been associated with difficulties recognizing and responding to social cues. Neuroimaging studies have begun to map the social brain; however, the specific neural substrates contributing to social deficits in neurodevelopmental disorders remain unclear. Three hundred and twelve children underwent structural magnetic resonance imaging of the brain (controls = 32, OCD = 44, ADHD = 77, ASD = 159; mean age = 11). Their social deficits were quantified on the Social Communication Questionnaire (SCQ) and the Reading the Mind in the Eyes Test (RMET). Multivariable regression models were used to examine the structural neuroimaging correlates of social deficits, with both a region of interest and a whole-brain vertex-wise approach. For the region of interest analysis, social brain regions were grouped into three networks: (1) lateral mentalization (e.g., temporal-parietal junction), (2) frontal cognitive (e.g., orbitofrontal cortex), and (3) subcortical affective (e.g., limbic system) regions. Overall, social communication deficits on the SCQ were associated with thinner cortices in the left lateral regions and the right insula, and decreased volume in the ventral striatum, across diagnostic groups (p = 0.006 to <0.0001). Smaller subcortical volumes were associated with more severe social deficits on the SCQ in ASD and ADHD, and less severe deficits in OCD. On the RMET, larger amygdala/hippocampal volumes were associated with fewer deficits across groups. Overall, patterns of associations were similar in ASD and ADHD, supporting a common underlying biology and the blurring of the diagnostic boundaries between these disorders.
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