Evidence map›Paper›PMID 30718427›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Movement dynamics of divisome proteins and PBP2x:FtsW in cells of

Amilcar J Perez, Yann Cesbron, Sidney L Shaw, Jesus Bazan Villicana, Ho-Ching T Tsui, Michael J Boersma, Ziyun A Ye, Yanina Tovpeko, Cees Dekker, Seamus Holden and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 139 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. FtsZ-mediated spatial-temporal control over septal cell wall synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Direct Quantification of Protein-Protein Interactions in Living Bacterial Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. How do spherical bacteria regulate cell division?Biochemical Society transactions · 2025
    Review
  10. Article
  11. GTPase activity regulates FtsZ ring positioning inMolecular biology of the cell · 2024
    Article
  12. Biological puzzles solved by usingJournal of bacteriology · 2024
    Review
  13. Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Amilcar J PerezDepartment of Biology, Indiana University, Bloomington, IN 47405-7005.
Yann CesbronCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX Newcastle upon Tyne, United Kingdom.
Sidney L ShawDepartment of Biology, Indiana University, Bloomington, IN 47405-7005.
Jesus Bazan VillicanaDepartment of Biology, Indiana University, Bloomington, IN 47405-7005.
Ho-Ching T TsuiDepartment of Biology, Indiana University, Bloomington, IN 47405-7005.
Michael J BoersmaDepartment of Biology, Indiana University, Bloomington, IN 47405-7005.
Ziyun A YeDepartment of Biology, Indiana University, Bloomington, IN 47405-7005.
Yanina TovpekoDepartment of Biology, Indiana University, Bloomington, IN 47405-7005.
Cees DekkerDepartment of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2628 CD Delft, The Netherlands.
Seamus HoldenCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX Newcastle upon Tyne, United Kingdom.
Malcolm E WinklerDepartment of Biology, Indiana University, Bloomington, IN 47405-7005; winklerm@indiana.edu.
Indiana University Bloomington · USNewcastle University · GBDelft University of Technology · NL

Funding

New Regulatory Interactions and Circuits that Mediate the Dynamics, Homeostasis, and Stress Responses of Peptidoglycan Synthesis in the Superbug Streptococcus pneumoniaeR35GM131767 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI MALCOLM E. WINKLER · 2019 to 2026
$4.8M
Dynamics of bacterial peptidoglycan synthesisR01GM113172 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI BRUN, YVES V, VANNIEUWENHZE, MICHAEL S · 2015 to 2018
$3.5M
Mechanisms of Chemokine Killing and Resistance of Streptococcus pneumoniaeR01GM114315 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI WINKLER, MALCOLM E. · 2015 to 2018
$1.1M
Spaciotemporal Regulation of Specific Penicillin Binding Protein (PBP) Function Determined by New Activity-Based ApproachesR01GM128439 · NIGMS · UNIVERSITY OF MINNESOTA · PI CARLSON, ERIN ELIZABETH, WINKLER, MALCOLM E. · 2018 to 2019
$936k
Graduate Program in Quantitative and Chemical Biology at Indiana University BloomT32GM109825 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 2014 to 2018
$926k
New Regulatory Circuits that Mediate Peptidoglycan Homeostasis and Cell Wall Stress Responses in the Superbug Streptococcus pneumoniaeR01GM127715 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI WINKLER, MALCOLM E. · 2018 to 2019
$630k
Acquisition of a DeltaVision OMX-SR Imaging SystemS10OD024988 · OD · INDIANA UNIVERSITY INDIANAPOLIS · PI WALCZAK, CLAIRE E · 2018 to 2018
$600k
NIGMS NIH HHS R01 GM113172NIGMS NIH HHS R01 GM114315NIGMS NIH HHS R01 GM127715NIGMS NIH HHS R01 GM128439NIGMS NIH HHS R35 GM131767NIGMS NIH HHS T32 GM109825NIH HHS S10 OD024988Wellcome Trust 206670/Z/17/7Wellcome Trust 206670/Z/17/Z
6 · The paper itself

Abstract

Bacterial cell division and peptidoglycan (PG) synthesis are orchestrated by the coordinated dynamic movement of essential protein complexes. Recent studies show that bidirectional treadmilling of FtsZ filaments/bundles is tightly coupled to and limiting for both septal PG synthesis and septum closure in some bacteria, but not in others. Here we report the dynamics of FtsZ movement leading to septal and equatorial ring formation in the ovoid-shaped pathogen,

Indexed as

Bacterial ProteinsCell DivisionCytoskeletal ProteinsCytoskeletonEscherichia coliGTP PhosphohydrolasesHumansMembrane ProteinsMicroscopy, FluorescencePenicillin-Binding ProteinsPeptidoglycanPneumococcal InfectionsStreptococcus pneumoniaeBacterial ProteinsCytoskeletal ProteinsFtsW protein, BacteriaGTP PhosphohydrolasesMembrane ProteinsPBP 2x protein, StreptococcusPenicillin-Binding ProteinsPeptidoglycanFtsZ treadmillingmicrohole vertical imagingnascent ring formationPBP2x:FtsW shared dynamicsTIRF microscopy

Identifiers

PMID30718427
PMCPMC6386697
OpenAlexW2911983544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.