Evidence map›Paper›PMID 30718415›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding.

Guey-Ying Liao, Clint E Kinney, Juan Ji An, Baoji Xu

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. The DMHAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Regulation of Satiety byBiomolecules · 2023
    Article
  10. Review
  11. RIIβ-PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Guey-Ying LiaoDepartment of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458.
Clint E KinneyDepartment of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458.
Juan Ji AnDepartment of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458.
Baoji XuDepartment of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458 bxu@scripps.edu.ORCID 0000-0002-2416-6633
Scripps Research Institute · US

Funding

TrkB Neurons in the Control of Body WeightR01DK105954 · NIDDK · UNIVERSITY OF FLORIDA · PI XU, BAOJI · 2016 to 2022
$4.6M
Unraveling the Role of PVH BDNF Neurons in Energy BalanceR01DK103335 · NIDDK · UNIVERSITY OF FLORIDA · PI XU, BAOJI · 2015 to 2022
$4.4M
NIDDK NIH HHS R01 DK103335NIDDK NIH HHS R01 DK105954
6 · The paper itself

Abstract

Genetic evidence indicates that brain-derived neurotrophic factor (BDNF) signaling through the TrkB receptor plays a critical role in the control of energy balance. Mutations in the

Indexed as

AnimalsBrain-Derived Neurotrophic FactorEatingEnergy MetabolismGABAergic NeuronsGene Expression RegulationHomeostasisHumansHypothalamusMembrane GlycoproteinsMiceObesityPhotoperiodProtein-Tyrosine KinasesReceptors, LeptinReceptor, trkBBdnf protein, mouseBrain-Derived Neurotrophic Factorleptin receptor, mouseMembrane GlycoproteinsNtrk2 protein, mouseProtein-Tyrosine KinasesReceptors, LeptinReceptor, trkBdorsomedial hypothalamusenergy expenditurefood intakeobesityTrkB

Identifiers

PMID30718415
PMCPMC6386673
OpenAlexW2914091513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.